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Details on Person DNA replication depends on the coordinated action of numerou...
| Class:Id | Summation:1598462 |
|---|---|
| _displayName | DNA replication depends on the coordinated action of numerou... |
| _timestamp | 2011-09-12 23:26:25 |
| created | [InstanceEdit:1597829] Higgins, JA, 2007-08-01 |
| literatureReference | [LiteratureReference:1600739] Genome-wide Analysis of the Core DNA Replication Machinery in the Higher Plants Arabidopsis and Oryza sativa |
| modified | [InstanceEdit:1597767] Higgins, JA, 2007-10-19 [InstanceEdit:1601927] Preece, J, 2011-09-12 |
| text | DNA replication depends on the coordinated action of numerous multi-protein complexes. At the simplest level, it requires an initiator to establish the site of replication initiation, a helicase to unwind DNA, a polymerase to synthesize new DNA, and machinery to process the Okazaki fragments generated during discontinuous synthesis. The basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, such as Saccharomyces cerevisiae (budding yeast), is well understood and has served as a model for studies of DNA replication initiation in multicellular eukaryotes. Genome-wide bioinformatic analyses of Arabidopsis (Arabidopsis thaliana) and rice (Oryza sativa) with published experimental data has provided a comprehensive view of the core DNA replication machinery in plants. Results indicate that core DNA replication machinery from plants is more similar to vertebrates than to single-celled yeasts, suggesting that animal models may be more relevant to plant systems. Analyses also indicated that plants may be unique among eukaryotes in that they have multiple copies of numerous core DNA replication genes. |
| (summation) | [Pathway:1598626] Synthesis of DNA [Arabidopsis thaliana] |
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