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Details on Person GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX)

Class:Id	Reaction:159803
_displayName	GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX)
_doRelease	TRUE
_timestamp	2016-11-10 00:56:35
catalystActivity	[CatalystActivity:159812] gamma-glutamyl carboxylase activity of GGCX [endoplasmic reticulum membrane]
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:159817] D'Eustachio, P, 2005-03-17 16:24:57
input	[EntityWithAccessionedSequence:159765] 3OHD110-F9(29-461) [endoplasmic reticulum lumen] [Homo sapiens] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:159751] CO2 [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:6806362] MK4 [endoplasmic reticulum lumen] [SimpleEntity:6806362] MK4 [endoplasmic reticulum lumen] [SimpleEntity:6806362] MK4 [endoplasmic reticulum lumen] [SimpleEntity:6806362] MK4 [endoplasmic reticulum lumen] [SimpleEntity:6806362] MK4 [endoplasmic reticulum lumen] [SimpleEntity:6806362] MK4 [endoplasmic reticulum lumen] [SimpleEntity:6806362] MK4 [endoplasmic reticulum lumen] [SimpleEntity:6806362] MK4 [endoplasmic reticulum lumen] [SimpleEntity:6806362] MK4 [endoplasmic reticulum lumen] [SimpleEntity:6806362] MK4 [endoplasmic reticulum lumen] [SimpleEntity:6806362] MK4 [endoplasmic reticulum lumen] [SimpleEntity:6806362] MK4 [endoplasmic reticulum lumen]
literatureReference	[LiteratureReference:159755] The vitamin K-dependent carboxylase [LiteratureReference:159753] Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid [LiteratureReference:163831] Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate. [LiteratureReference:159750] Tethered processivity of the vitamin K-dependent carboxylase: factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo [LiteratureReference:159725] Factor IX San Dimas. Substitution of glutamine for Arg-4 in the propeptide leads to incomplete gamma-carboxylation and altered phospholipid binding properties.
modified	[InstanceEdit:162516] D'Eustachio, P, 2005-03-29 15:32:08 [InstanceEdit:163835] D'Eustachio, P, 2005-05-07 21:30:29 [InstanceEdit:164453] D'Eustachio, P, 2005-05-19 19:30:13 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:6806368] D'Eustachio, Peter, 2015-10-22 [InstanceEdit:6806680] D'Eustachio, Peter, 2015-10-23 [InstanceEdit:6806888] D'Eustachio, Peter, 2015-10-27 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) pro-factor IX, uncarboxylated + 12 CO2 + 12 O2 + 12 vitamin K hydroquinone -> pro-factor IX + 12 H2O + 12 vitamin K epoxide
output	[EntityWithAccessionedSequence:159866] 12xCbxE-3D-F9(29-461) [endoplasmic reticulum lumen] [Homo sapiens] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:6806366] MK4 epoxide [endoplasmic reticulum lumen] [SimpleEntity:6806366] MK4 epoxide [endoplasmic reticulum lumen] [SimpleEntity:6806366] MK4 epoxide [endoplasmic reticulum lumen] [SimpleEntity:6806366] MK4 epoxide [endoplasmic reticulum lumen] [SimpleEntity:6806366] MK4 epoxide [endoplasmic reticulum lumen] [SimpleEntity:6806366] MK4 epoxide [endoplasmic reticulum lumen] [SimpleEntity:6806366] MK4 epoxide [endoplasmic reticulum lumen] [SimpleEntity:6806366] MK4 epoxide [endoplasmic reticulum lumen] [SimpleEntity:6806366] MK4 epoxide [endoplasmic reticulum lumen] [SimpleEntity:6806366] MK4 epoxide [endoplasmic reticulum lumen] [SimpleEntity:6806366] MK4 epoxide [endoplasmic reticulum lumen] [SimpleEntity:6806366] MK4 epoxide [endoplasmic reticulum lumen]
precedingEvent	[Reaction:159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) [Homo sapiens] [Reaction:159803] GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) [Homo sapiens] [Reaction:159761] GGCX gamma-carboxylates F7(21-466) (pro-factor VII) [Homo sapiens] [Reaction:159819] GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) [Homo sapiens] [Reaction:159826] GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) [Homo sapiens] [Reaction:159795] GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) [Homo sapiens] [Reaction:159752] GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) [Homo sapiens] [Reaction:163820] GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) [Homo sapiens] [Reaction:163810] GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6) [Homo sapiens] [Reaction:6807214] GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) [Homo sapiens] [Reaction:6806674] UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) [Homo sapiens]
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361995] R-HSA-159803.4
summation	[Summation:179103] GGCX (gamma glutamyl carboxylase) in the endoplasmic reticul...
(hasEvent)	[Pathway:159740] Gamma-carboxylation of protein precursors [Homo sapiens]
(normalReaction)	[FailedReaction:9673231] GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX) [Homo sapiens]
(precedingEvent)	[Reaction:159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) [Homo sapiens] [BlackBoxEvent:159836] Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9783859] Update Tracker - [Reaction:159803] GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) - v55:[add_removeInput, add_removeOutput, modifyText]
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