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Details on Person Formation of NRF2

Class:Id	Reaction:1592240
_displayName	Formation of NRF2
_doRelease	TRUE
_timestamp	2014-11-20 02:37:50
authored	[InstanceEdit:1592225] May, B, 2011-08-20
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1592237] May, B, 2011-09-09
edited	[InstanceEdit:1592225] May, B, 2011-08-20
input	[EntityWithAccessionedSequence:1592206] GABPA [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1592201] NRF2 beta-1 subunit [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1592200] NRF2 beta-2 subunit [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1592216] NRF2 gamma-1 subunit [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1592211] NRF2 gamma-2 subunit [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1592176] Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain
modified	[InstanceEdit:1605406] May, B, 2011-09-21 [InstanceEdit:3108240] May, B, 2013-02-10 [InstanceEdit:3189817] May, B, 2013-02-25 [InstanceEdit:4410479] May, B, 2013-08-23 [InstanceEdit:4420247] May, B, 2013-08-31 [InstanceEdit:5210064] May, B, 2013-12-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of NRF2
output	[Complex:1592226] NRF2 [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:1592234] Expression of GABPA (NRF2 alpha subunit) [Homo sapiens] [Reaction:1592244] AMPK phosphorylates PPARGC1A [Homo sapiens] [Reaction:1592233] p38 MAPK phosphorylates PPARGC1A [Homo sapiens]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5210062] Lezza, Angela M S, 2013-12-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644444] R-HSA-1592240.2
summation	[Summation:1605514] Five subunits (alpha, beta-1, beta-2, gamma-1, gamma-2) asse...
(hasEvent)	[Pathway:2151201] Transcriptional activation of mitochondrial biogenesis [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:1592235] Expression of POLG2 [Homo sapiens] [Reaction:1592236] NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter [Homo sapiens] [BlackBoxEvent:1592239] Expression of TWINKLE (TWNK, PEO1) [Homo sapiens] [BlackBoxEvent:1592241] Expression of SSBP1 [Homo sapiens] [BlackBoxEvent:1592243] Expression of POLRMT [Homo sapiens] [Reaction:1592250] NRF1, PPRC1:HCFC1:NRF2 bind the TFB1M promoter [Homo sapiens] [BlackBoxEvent:1592251] Expression of MTERF1 (mTERF) [Homo sapiens] [Reaction:2466367] NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter [Homo sapiens] [Reaction:2466392] NRF1:p-PPARGC1A, NRF2 bind the TFB2M promoter [Homo sapiens]
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No pathways have been reviewed or authored by Formation of NRF2 (1592240)