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Details on Person AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Class:IdLiteratureReference:1592184
_displayNameAMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
_timestamp2011-09-09 12:28:06
author[Person:1592183] Cantó, C
[Person:1592194] Gerhart-Hines, Z
[Person:400103] Feige, JN
[Person:1592188] Lagouge, M
[Person:1592185] Noriega, L
[Person:1592161] Milne, JC
[Person:1592191] Elliott, PJ
[Person:442518] Puigserver, P
[Person:186658] Auwerx, J
created[InstanceEdit:1592150] May, B, 2011-09-09
journalNature
pages1056-60
pubMedIdentifier19262508
titleAMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
volume458
year2009
(literatureReference)[RegulationReference:9642411] Positive gene expression regulation by 'p-PPARGC1A [nucleoplasm]' Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
[Pathway:1592230] Mitochondrial biogenesis [Homo sapiens]
[Reaction:1605475] Ampk phosphorylates Ppargc1a [Mus musculus]
[Pathway:2151209] Activation of PPARGC1A (PGC-1alpha) by phosphorylation [Homo sapiens]
[BlackBoxEvent:9854916] MITF-M-dependent SIRT1 gene expression [Homo sapiens]
[Reaction:9854920] MITF-M dimer binds SIRT1 promoter [Homo sapiens]
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