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Details on Person ZBP1 binds cytosolic DNA

Class:Id	Reaction:1591234
_displayName	ZBP1 binds cytosolic DNA
_doRelease	TRUE
_timestamp	2017-07-26 05:54:53
authored	[InstanceEdit:1606299] Shamovsky, V, 2011-09-21
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1591227] Shamovsky, V, 2011-09-08
edited	[InstanceEdit:2134527] Shamovsky, V, 2012-02-23
input	[EntityWithAccessionedSequence:1591229] ZBP1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1591229] ZBP1 [cytosol] [Homo sapiens] [DefinedSet:8982083] ZBP1 ligand [cytosol] [Human alphaherpesvirus 2]
isChimeric	FALSE
literatureReference	[LiteratureReference:1591232] DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response [LiteratureReference:1591236] Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules [LiteratureReference:1606296] The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA [LiteratureReference:1606294] Solution structure of the Zbeta domain of human DNA-dependent activator of IFN-regulatory factors and its binding modes to B- and Z-DNAs
modified	[InstanceEdit:1606299] Shamovsky, V, 2011-09-21 [InstanceEdit:2122961] Shamovsky, V, 2012-02-14 [InstanceEdit:2129343] Shamovsky, V, 2012-02-19 [InstanceEdit:2143411] Shamovsky, V, 2012-02-24 [InstanceEdit:3134795] Shamovsky, V, 2013-02-13 [InstanceEdit:3604377] Shamovsky, V, 2013-05-22 [InstanceEdit:9013879] Shamovsky, Veronica, 2017-07-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ZBP1 binds cytosolic DNA
output	[Complex:1591233] dsDNA:ZBP1 [cytosol] [Homo sapiens]
relatedSpecies	[Species:8982084] Human alphaherpesvirus 2 [Species:2671791] Human cytomegalovirus
releaseDate	2012-03-13
reviewed	[InstanceEdit:2023355] D'Eustachio, P, 2011-12-07 [InstanceEdit:2129340] Upton, JW, Mocarski, ES, 2012-02-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158051] R-HSA-1591234.3
summation	[Summation:1606309] ZBP1(DAI) binds to double-stranded DNA in vitro and in vivo ...
(hasEvent)	[Pathway:1606322] ZBP1(DAI) mediated induction of type I IFNs [Homo sapiens]
(precedingEvent)	[Reaction:1606324] Recruitment TBK1 to dsDNA:ZBP1 followed by its activation [Homo sapiens] [Reaction:1810457] ZBP1(DAI) recruits RIP1 and RIP3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780846] Update Tracker - [Reaction:1591234] ZBP1 binds cytosolic DNA - v62:[add_removeInput] [_UpdateTracker:9787347] Update Tracker - [Reaction:1591234] ZBP1 binds cytosolic DNA - v45:[modifyText] [_UpdateTracker:9787678] Update Tracker - [Reaction:1591234] ZBP1 binds cytosolic DNA - v44:[add_removeInput]
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