Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)

Class:Id	Reaction:159101
_displayName	NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)
_doRelease	TRUE
_timestamp	2025-11-04 07:15:50
authored	[InstanceEdit:159103] Joshi-Tope, G, 2005-02-17 16:25:28
catalystActivity	[CatalystActivity:8849114] ATP hydrolysis activity of polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643605] ATPase activity of polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:159634] Zhang, Z, Krainer, AR, 2005-03-11 19:55:50
edited	[InstanceEdit:165073] Joshi-Tope, G, 0000-00-00 00:00:00
goBiologicalProcess	[GO_BiologicalProcess:1101] RNA export from nucleus
input	[Complex:8849118] NXF1,2:NXT1 [nucleoplasm] [Homo sapiens] [Complex:156769] polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:8850607] Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP [LiteratureReference:8850632] TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export [LiteratureReference:8850641] Mapping interactions between mRNA export factors in living cells [LiteratureReference:8850630] Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1 [LiteratureReference:8850666] The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA [LiteratureReference:8850614] Chtop is a component of the dynamic TREX mRNA export complex [LiteratureReference:8849125] Binding of ATP to UAP56 is necessary for mRNA export [LiteratureReference:8850715] TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus [LiteratureReference:8850681] The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences [LiteratureReference:8850709] The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human [LiteratureReference:8850704] Analysis of the RNA binding specificity of the human tap protein, a constitutive transport element-specific nuclear RNA export factor [LiteratureReference:8850694] Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes [LiteratureReference:8932923] TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture
modified	[InstanceEdit:159337] Gillespie, ME, 2005-03-03 03:44:33 [InstanceEdit:159629] Joshi-Tope, G, 2005-03-12 00:08:35 [InstanceEdit:159637] Joshi-Tope, G, 2005-03-12 00:56:04 [InstanceEdit:162450] Joshi-Tope, G, 2005-03-28 18:56:42 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:8849163] May, Bruce, 2015-12-14 [InstanceEdit:8850669] May, Bruce, 2015-12-24 [InstanceEdit:8850672] May, Bruce, 2015-12-24 [InstanceEdit:8850739] May, Bruce, 2015-12-27 [InstanceEdit:8852187] May, Bruce, 2016-01-13 [InstanceEdit:8932932] May, Bruce, 2016-07-31 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9971062] Orlic-Milacic, Marija, 2025-11-04
name	NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) Recruitment of TAP to the EJC
output	[Complex:8849115] DDX39B:ADP [nucleoplasm] [Homo sapiens] [SimpleEntity:113550] Pi [nucleoplasm] [Complex:159100] NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:8849157] TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally [Homo sapiens] [BlackBoxEvent:9770847] Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	UPDATED
reviewed	[InstanceEdit:8852183] Wilson, Stuart A, 2016-01-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360929] R-HSA-159101.6
summation	[Summation:159102] The mRNA is transferred from ALYREF of the TREX complex to N...
(hasEvent)	[Pathway:159236] Transport of Mature mRNA derived from an Intron-Containing Transcript [Homo sapiens]
(precedingEvent)	[Reaction:75096] Docking of the TAP:EJC Complex with the NPC [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782742] Update Tracker - [Reaction:159101] NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) - v58:[addLiteratureReference] [_UpdateTracker:9783502] Update Tracker - [Reaction:159101] NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) - v56:[addCatalystActivity, addLiteratureReference, addOutput, add_removeInput, modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (159101)