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Details on Person The acetyl group from acetyl-CoA is transferred to NAT2

Class:Id	Reaction:158832
_displayName	The acetyl group from acetyl-CoA is transferred to NAT2
_doRelease	TRUE
_timestamp	2025-08-13 19:24:03
authored	[InstanceEdit:158834] Jassal, B, 2005-02-09 10:26:12
catalystActivity	[CatalystActivity:9954139] protein-cysteine S-acyltransferase activity of NAT2 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:158834] Jassal, B, 2005-02-09 10:26:12
input	[EntityWithAccessionedSequence:158692] NAT2 [cytosol] [Homo sapiens] [SimpleEntity:76183] Ac-CoA [cytosol]
internalReviewed	[InstanceEdit:9954159] D'Eustachio, Peter, 2025-06-06
literatureReference	[LiteratureReference:158835] Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism of polymorphic human NAT2.
modified	[InstanceEdit:158852] Jassal, B, 2005-02-10 08:00:29 [InstanceEdit:159373] Jassal, B, 2005-03-07 14:42:50 [InstanceEdit:174962] Jassal, B, 2006-02-23 11:52:06 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:353652] Jassal, Bijay, 2008-06-13 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9954140] D'Eustachio, Peter, 2025-06-06 [InstanceEdit:9963234] D'Eustachio, Peter, 2025-08-13
name	The acetyl group from acetyl-CoA is transferred to NAT2
output	[EntityWithAccessionedSequence:158833] AcC-NAT2 [cytosol] [Homo sapiens] [SimpleEntity:76194] CoA-SH [cytosol]
precedingEvent	[Reaction:174967] NAT2 acetylation [Homo sapiens] [Reaction:158832] The acetyl group from acetyl-CoA is transferred to NAT2 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2006-04-24
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54 [InstanceEdit:9963235] Hill, David P, 2025-08-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359455] R-HSA-158832.4
structureModified	[InstanceEdit:9954140] D'Eustachio, Peter, 2025-06-06
summation	[Summation:158838] N-acetylation occurs in two sequential steps via a ping-p...
(hasEvent)	[Pathway:156582] Acetylation [Homo sapiens]
(precedingEvent)	[Reaction:174967] NAT2 acetylation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9964788] Update Tracker - [Reaction:158832] The acetyl group from acetyl-CoA is transferred to NAT2 - v94:[removeCatalystActivity]
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