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Details on Person Plasminogen activator inhibitor 1, a serpin, binds to fibrin...

Class:IdSummation:158799
_displayNamePlasminogen activator inhibitor 1, a serpin, binds to fibrin...
_timestamp2005-02-10 21:54:37
created[InstanceEdit:158796] D'Eustachio, P, 2005-02-08 22:51:14
literatureReference[LiteratureReference:158798] Interaction between plasminogen activator inhibitor type 1 (PAI-1) bound to fibrin and either tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). Binding of t-PA/PAI-1 complexes to fibrin mediated by both the finger and the kringle-2 domain of t-PA.
[LiteratureReference:158881] Deficient t-PA release and elevated PA inhibitor levels in patients with spontaneous or recurrent deep venous thrombosis
modified[InstanceEdit:158898] D'Eustachio, P, 2005-02-10 21:54:28
textPlasminogen activator inhibitor 1, a serpin, binds to fibrin-associated tissue plasminogen activator. The resulting stable complex remains associated with fibrin but cannot activate plasminogen (Wagner et al. 1989). The importance of this step in the regulation of clot dissolution in vivo is indicated by the occurence of thrombosis in individuals with abnormally little tissue plasminogen activator or abnormally much plasminogen activator inhibitor (Juhan-Vague et al. 1987).
(summation)[Reaction:158795] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 [Homo sapiens]
[Reaction:158800] fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 [Homo sapiens]
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