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Details on Person SERPINE1 [extracellular region]

Class:IdEntityWithAccessionedSequence:158797
_displayNameSERPINE1 [extracellular region]
_timestamp2013-05-03 18:44:15
compartment[Compartment:984] extracellular region
created[InstanceEdit:158796] D'Eustachio, P, 2005-02-08 22:51:14
endCoordinate402
modified[InstanceEdit:158917] D'Eustachio, P, 2005-02-14 18:02:12
[InstanceEdit:2466194] Jupe, S, 2012-09-06
[InstanceEdit:2534268] Jupe, S, 2012-10-24
[InstanceEdit:3322333] Wu, G, 2013-05-03
[InstanceEdit:3322334] Wu, G, 2013-05-03
[InstanceEdit:3448660] Wu, G, 2013-05-16
nameSERPINE1
Plasminogen activator inhibitor-1
PAI1
referenceEntity[ReferenceGeneProduct:61272] UniProt:P05121 SERPINE1 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:366885] R-HSA-158797.1
startCoordinate24
(hasComponent)[Complex:158789] fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 [extracellular region] [Homo sapiens]
[Complex:158791] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 [extracellular region] [Homo sapiens]
[Complex:2466242] Vitronectin:Plasminogen activator inhibitor 1 [extracellular region] [Homo sapiens]
[Complex:9655836] SERPINE1:factor XIa:GPIb:GPIX:GPV complex [plasma membrane] [Homo sapiens]
(hasMember)[DefinedSet:481033] Platelet alpha granule contents [extracellular region] [Homo sapiens]
[CandidateSet:4127463] SERPINE1-like proteins [extracellular region] [Homo sapiens]
[CandidateSet:8957977] IL3 upregulated extracellular proteins [extracellular region] [Homo sapiens]
[DefinedSet:8960998] IL1B upregulated extracellular proteins [extracellular region] [Homo sapiens]
[DefinedSet:8961376] IL6 upregulated extracellular proteins [extracellular region] [Homo sapiens]
(input)[Reaction:158795] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 [Homo sapiens]
[Reaction:158800] fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1 [Homo sapiens]
[Reaction:159005] urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR [Homo sapiens]
[Reaction:2396079] VTN binds Plasminogen activator inhibitor- 1 [Homo sapiens]
[Reaction:9655851] factor XIa binds SERPINE1 [Homo sapiens]
(output)[BlackBoxEvent:549364] Expression of SERPINE1 (PAI-1) [Homo sapiens]
[BlackBoxEvent:2106586] WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it [Homo sapiens]
[BlackBoxEvent:5628884] TP53 and BRD7 positively regulate expression of TP53 targets [Homo sapiens]
[BlackBoxEvent:9644463] Expression of SERPINE1 regulated by NR3C2, AP-1 [Homo sapiens]
[BlackBoxEvent:9846556] GOCAM WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it [Homo sapiens]
[BlackBoxEvent:9926525] MITF-M-dependent SERPINE1 gene expression [Homo sapiens]
(replacementInstances)[_Deleted:9763865] Deletion of instance: 61271
(updatedInstance)[_UpdateTracker:9873912] Update Tracker - [EntityWithAccessionedSequence:158797] SERPINE1 [extracellular region] - v43:[modifyName]
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No pathways have been reviewed or authored by SERPINE1 [extracellular region] (158797)
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