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Details on Person crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin

Class:Id	Reaction:158750
_displayName	crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin
_doRelease	TRUE
_timestamp	2016-11-10 00:55:39
authored	[InstanceEdit:158778] D'Eustachio, P, 2005-02-08 21:36:34
catalystActivity	[CatalystActivity:158768] serine-type endopeptidase activity of fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:158778] D'Eustachio, P, 2005-02-08 21:36:34
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
input	[Complex:158777] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:158755] Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin. [LiteratureReference:158752] The single-chain form of tissue-type plasminogen activator has catalytic activity: studies with a mutant enzyme that lacks the cleavage site [LiteratureReference:5333754] The crystal structure of a complex of p11 with the annexin II N-terminal peptide [LiteratureReference:5333700] Annexin A2 system in human biology: cell surface and beyond [LiteratureReference:5333724] The annexin A2/S100A10 system in health and disease: emerging paradigms
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:5333641] Jassal, Bijay, 2014-02-20 [InstanceEdit:5674209] Jassal, Bijay, 2015-02-11 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin
output	[Complex:158764] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region] [Homo sapiens] [Complex:158770] Plasmin [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:158784] crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen [Homo sapiens] [Reaction:158781] crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) [Homo sapiens] [Reaction:158721] histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen [Homo sapiens]
regulatedBy	[PositiveRegulation:5336140] Positive regulation by 'ANXA2:S100A10 tetramer [external side of plasma membrane]'
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5674206] Jassal, Bijay, 2015-02-11
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360650] R-HSA-158750.4
summation	[Summation:158749] Plasminogen bound to fibrin is cleaved and activated by tiss...
(hasEvent)	[Pathway:75205] Dissolution of Fibrin Clot [Homo sapiens]
(precedingEvent)	[Reaction:158747] crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) [Homo sapiens] [Reaction:158766] fibrin multimer, crosslinked -> fibrin digestion products (plasmin) [Homo sapiens] [Reaction:158893] alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786492] Update Tracker - [Reaction:158750] crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin - v49:[addRegulator] [_UpdateTracker:9786737] Update Tracker - [Reaction:158750] crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin - v48:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin (158750)