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Details on Person TPMT transfers CH3 from AdoMet to 6MP

Class:Id	Reaction:158609
_displayName	TPMT transfers CH3 from AdoMet to 6MP
_doRelease	TRUE
_timestamp	2016-11-10 00:55:04
catalystActivity	[CatalystActivity:158629] thiopurine S-methyltransferase activity of TPMT [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:158630] Jassal, B, 2005-02-03 14:13:47
input	[SimpleEntity:158619] 6MP [cytosol] [SimpleEntity:71284] AdoMet [cytosol]
literatureReference	[LiteratureReference:158621] Metabolism of thiopyrimidines and thiopurines. S-Methylation with S-adenosylmethionine transmethylase and catabolism in mammalian tissues. [LiteratureReference:158627] Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase [LiteratureReference:176025] The thiopurines: an update [LiteratureReference:176020] Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations [LiteratureReference:5618154] Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia
modified	[InstanceEdit:158852] Jassal, B, 2005-02-10 08:00:29 [InstanceEdit:174378] Jassal, Bijay, 2006-02-17 [InstanceEdit:176027] Jassal, B, 2006-02-28 12:02:08 [InstanceEdit:176088] Jassal, B, 2006-03-03 14:00:07 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:353652] Jassal, Bijay, 2008-06-13 [InstanceEdit:686117] Jassal, B, 2010-05-06 [InstanceEdit:5603083] Jassal, Bijay, 2014-06-27 [InstanceEdit:5622022] Jassal, Bijay, 2014-09-08 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TPMT transfers CH3 from AdoMet to 6MP 6-mercaptopurine can be S-methylated
output	[SimpleEntity:158611] 6MMP [cytosol] [SimpleEntity:71285] AdoHcy [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:76386] CYP1A2 S-demethylates 6MMP [Homo sapiens] [Reaction:174391] MAT1A multimers transfer Ado from ATP to L-Met [Homo sapiens] [Reaction:1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY [Homo sapiens] [Reaction:5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS [Homo sapiens] [Reaction:174374] MTR transfers CH3 from MeCbl to HCYS [Homo sapiens] [Reaction:1237102] Transamination of MOB to methionine [Homo sapiens] [Reaction:5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met [Homo sapiens]
releaseDate	2006-04-24
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360491] R-HSA-158609.3
summation	[Summation:176023] Methylation is the major biotransformation route of thiopuri...
(hasEvent)	[Pathway:156581] Methylation [Homo sapiens]
(normalReaction)	[FailedReaction:5603379] TPMT does not transfer CH3 from AdoMet to 6MP [Homo sapiens]
(precedingEvent)	[Reaction:174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786232] Update Tracker - [Reaction:158609] TPMT transfers CH3 from AdoMet to 6MP - v50:[addLiteratureReference, modifyText] [_UpdateTracker:9790604] Update Tracker - [Reaction:158609] TPMT transfers CH3 from AdoMet to 6MP - v33:[addOutput]
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