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Details on Person factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)

Class:Id	Reaction:158419
_displayName	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)
_doRelease	TRUE
_timestamp	2025-01-07 02:26:37
authored	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
catalystActivity	[CatalystActivity:139890] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
input	[Complex:158162] factor XI:GPIb-IX-V complex [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:158151] Factor XII-independent activation of factor XI in plasma: effects of sulfatides on tissue factor-induced coagulation [LiteratureReference:158341] Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in the presence of negatively charged surfaces. [LiteratureReference:158132] Thrombin activates factor XI on activated platelets in the absence of factor XII [LiteratureReference:9934201] Thrombin activation of the factor XI dimer is a multistaged process for each subunit [LiteratureReference:9934220] Factor XI contributes to thrombin generation in the absence of factor XII
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:352550] D'Eustachio, P, 2008-06-03 23:47:06 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9861372] D'Eustachio, Peter, 2024-02-17 [InstanceEdit:9934232] Shamovsky, Veronica, 2025-01-07
name	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)
output	[Complex:158130] factor XIa:GPIb:GPIX:GPV complex [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) [Homo sapiens] [Reaction:140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) [Homo sapiens] [Reaction:158145] factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex [Homo sapiens]
regulatedBy	[NegativeRegulation:5607094] Negative regulation by 'Extracellular thrombin inactivating complexes [extracellular region]' [NegativeRegulation:5607787] Negative regulation by 'SERPINE2:GAG:activated thrombin (factor IIa) [plasma membrane]' [NegativeRegulation:9015384] Negative regulation by 'Factor IIa inhibitors:IIa [extracellular region]'
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358512] R-HSA-158419.7
summation	[Summation:158284] This Reactome event describes thrombin-catalyzed cleavage of... [Summation:9603336] Some direct oral anticoagulant (DOAC) drugs are potent, comp...
(hasEvent)	[Pathway:140837] OBSOLETE_Intrinsic Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9970672 [Homo sapiens] [Pathway:9769743] Amplification and propagation of coagulation cascade [Homo sapiens]
(precedingEvent)	[Reaction:158333] factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) [Homo sapiens] [Reaction:9653838] factor XIa binds SERPING1 [Homo sapiens] [Reaction:9655851] factor XIa binds SERPINE1 [Homo sapiens] [Reaction:9657706] factor XIa binds APP(18-770) [Homo sapiens] [Reaction:9936467] factor IX -> factor IXa + factor IX activation peptide (kallikrein catalyst) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776000] Update Tracker - [Reaction:158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - v78:[addSummation] [_UpdateTracker:9779647] Update Tracker - [Reaction:158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - v65:[addRegulator] [_UpdateTracker:9780057] Update Tracker - [Reaction:158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - v64:[removeRegulator] [_UpdateTracker:9780385] Update Tracker - [Reaction:158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - v63:[modifyText] [_UpdateTracker:9780628] Update Tracker - [Reaction:158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - v62:[addRegulator, modifyText] [_UpdateTracker:9786163] Update Tracker - [Reaction:158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - v50:[addRegulator] [_UpdateTracker:9864018] Update Tracker - [Reaction:158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - v88:[modifyText, removeLiteratureReference] [_UpdateTracker:9939780] Update Tracker - [Reaction:158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - v92:[modifyText, removeLiteratureReference]
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No pathways have been reviewed or authored by factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (158419)