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Details on Person Zn2+ [extracellular region]

Class:IdSimpleEntity:158417
_displayNameZn2+ [extracellular region]
_timestamp2011-11-02 11:55:09
compartment[Compartment:984] extracellular region
created[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
crossReference[DatabaseIdentifier:29427] COMPOUND:C00038
modified[InstanceEdit:264766] D'Eustachio, P, 2008-04-06 23:06:04
[InstanceEdit:1914819] Jupe, S, 2011-11-02
[InstanceEdit:9616752] Shorser, Solomon, 2018-08-13
[InstanceEdit:9619952] Wu, G, 2018-09-19
[InstanceEdit:9989189] Weiser, Joel, 2026-05-17
nameZn2+
zinc(2+)
Zn++
Zinc ion
Zn(II)
referenceEntity[ReferenceMolecule:114751] zinc(2+) [ChEBI:29105]
stableIdentifier[StableIdentifier:366839] R-ALL-158417.3
(hasComponent)[Complex:190020] BoNT Type B precursor [extracellular region] [Clostridium botulinum]
[Complex:190021] BoNT/G LC:Zn2+ disulfide bonded [extracellular region] [Clostridium botulinum]
[Complex:190022] botB LC:Zn2+ disulfide bonded [extracellular region] [Clostridium botulinum]
[Complex:190023] BoNT Type G precursor [extracellular region] [Clostridium botulinum]
[Complex:190034] BoNT/F LC:Zn2+ disulfide bonded [extracellular region] [Clostridium botulinum]
[Complex:190037] BoNT/D LC:Zn2+ disulfide bonded [extracellular region] [Clostridium botulinum]
[Complex:190039] BoNT Type D precursor [extracellular region] [Clostridium botulinum]
[Complex:190040] BoNT Type E precursor [extracellular region] [Clostridium botulinum]
[Complex:190041] BoNT Type F precursor [extracellular region] [Clostridium botulinum]
[Complex:190044] BoNT/E LC:Zn2+ disulfide bonded [extracellular region] [Clostridium botulinum]
List all 38 refering instances
(hasMember)[DefinedSet:790205] Ligands of GPCRs that activate Gs [extracellular region] [Homo sapiens]
[DefinedSet:791492] Ligands of GPCRs that activate Gq/11 [extracellular region] [Homo sapiens]
(input)[Reaction:429356] insulin detemir selfassociation into hexamers at injection site [Homo sapiens]
[Reaction:442317] ZIP6 and ZIP14 mediate zinc influx into cells [Homo sapiens]
[Reaction:442319] mZIP5 mediates zinc uptake by cells [Mus musculus]
[Reaction:442345] hZIP10 mediates zinc influx into cells [Homo sapiens]
[Reaction:442359] rZip10 mediates zinc influx into cells [Rattus norvegicus]
[Reaction:442387] ZIP8 mediates zinc influx into cells [Homo sapiens]
[Reaction:442405] hZIP5 mediates zinc uptake by cells [Homo sapiens]
[Reaction:442422] SLC39A1-4 transports Zn2+ from extracellular region to cytosol [Homo sapiens]
[Reaction:444572] Zinc is an agonist of GPR39 [Homo sapiens]
[Reaction:1119822] Zn2++ATP+H2O->Zn2++ADP+phosphate [Oryza sativa]
List all 15 refering instances
(output)[BlackBoxEvent:265166] Exocytosis of Insulin [Homo sapiens]
[Reaction:429338] insulin detemir hexamer dissociates [Homo sapiens]
[Reaction:429380] Insulin Glargine hexamer dissociates [Homo sapiens]
[Reaction:435366] ZnT1 mediates the efflux of zinc from the cell [Homo sapiens]
(regulator)[Requirement:158223] Requirement by 'Zn2+ [extracellular region]'
[Requirement:159017] Requirement by 'Zn2+ [extracellular region]'
[NegativeRegulation:5339572] Negative regulation by 'Zn2+ [extracellular region]'
[PositiveRegulation:6799964] Positive regulation by 'Zn2+ [extracellular region]'
[PositiveRegulation:9034633] Positive regulation by 'Zn2+ [extracellular region]'
(requiredInputComponent)[BlackBoxEvent:9822532] ADAMTS13 cleaves VWF multimer [Homo sapiens]
[BlackBoxEvent:9844241] ADAMTS13 cleaves VWF variant multimer [Homo sapiens]
[Reaction:9855685] factor XII + prekallikrein:kininogen:cell surface receptor -> prekallikrein:kininogen:cell surface receptor:factor XII [Homo sapiens]
[Reaction:9855705] factor XII + polyanionic activator -> factor XII:polyanionic activator (in plasma) [Homo sapiens]
[BlackBoxEvent:9934645] ADAMTS13 cleaves VWF multimer bound to FVIII [Homo sapiens]
[Reaction:9936904] factor XII + prekallikrein:kininogen + β-amyloid fibril:Zn2+ -> prekallikrein:kininogen:β-amyloid fibril:Zn2+:factor XII [Homo sapiens]
[Reaction:9936909] factor XII + β-amyloid fibril:Zn2+ -> factor XII:β-amyloid fibril:Zn2+ [Homo sapiens]
(updatedInstance)[_UpdateTracker:9867383] Update Tracker - [SimpleEntity:158417] Zn2+ [extracellular region] - v25:[addName]
[_UpdateTracker:9889810] Update Tracker - [SimpleEntity:158417] Zn2+ [extracellular region] - v52:[addName]
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No pathways have been reviewed or authored by Zn2+ [extracellular region] (158417)
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