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Details on Person factor XIIa binds SERPING1

Class:Id	Reaction:158357
_displayName	factor XIIa binds SERPING1
_doRelease	TRUE
_timestamp	2026-01-27 16:19:46
authored	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
goBiologicalProcess	[GO_BiologicalProcess:1221431] negative regulation of blood coagulation, intrinsic pathway
input	[Complex:158306] factor XIIa [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:158296] SERPING1 [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:158222] Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization [LiteratureReference:158168] The regulation of human factor XIIa by plasma proteinase inhibitors [LiteratureReference:158371] Inhibition by C1INH of Hagemann factor fragment activation of coagulation, fibrinolysis, and kinin generation
modified	[InstanceEdit:158424] D'Eustachio, P, 2005-01-20 14:48:32 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9660295] Shamovsky, Veronica, 2019-09-09 [InstanceEdit:9674491] Shamovsky, Veronica, 2020-01-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9980357] Shamovsky, Veronica, 2026-01-27
name	factor XIIa binds SERPING1 factor XIIa + C1Inh -> factor XIIa:C1Inh
output	[Complex:158141] factor XIIa:C1Inh [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:158313] factor XII -> factor XIIa [Homo sapiens] [Reaction:158311] OBSOLETE_kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin_REPLACEMENT_9938539 [Homo sapiens] [Reaction:9655850] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst) [Homo sapiens] [Reaction:9857945] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (PRCP catalyst) [Homo sapiens] [BlackBoxEvent:9650473] SERPING1 is secreted [Homo sapiens]
releaseDate	2005-04-11
reviewed	[InstanceEdit:9980333] Schmaier, Alvin H, 2026-01-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360026] R-HSA-158357.6
summation	[Summation:158325] Activated factor XII (factor XIIa) binds to the plasma prote...
(hasEvent)	[Pathway:140837] OBSOLETE_Intrinsic Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9970672 [Homo sapiens] [Pathway:9855719] Regulation of FXIIa and plasma kallikrein activity [Homo sapiens]
(normalReaction)	[FailedReaction:9651456] SERPING1 variant does not bind factor XIIa [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9984688] Update Tracker - [Reaction:158357] factor XIIa binds SERPING1 - v96:[modifyText]
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No pathways have been reviewed or authored by factor XIIa binds SERPING1 (158357)