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Details on Person kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin

Class:Id	Reaction:158340
_displayName	kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin
_doRelease	TRUE
_timestamp	2026-01-27 16:20:00
authored	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
goBiologicalProcess	[GO_BiologicalProcess:1221431] negative regulation of blood coagulation, intrinsic pathway
input	[Complex:158140] Plasma kallikrein [extracellular region] [Homo sapiens] [Complex:158255] A2M tetramer [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:158405] Distribution of plasma kallikrein between C-1 inactivator and alpha 2-macroglobulin in plasma utilizing a new assay for alpha 2-macroglobulin-kallikrein complexes [LiteratureReference:158326] Primary structure of human alpha 2-macroglobulin. V. The complete structure.
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:167229] D'Eustachio, P, 2005-10-13 14:50:40 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9674491] Shamovsky, Veronica, 2020-01-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9935204] Shamovsky, Veronica, 2025-01-13 [InstanceEdit:9979567] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980357] Shamovsky, Veronica, 2026-01-27
name	kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin
output	[Complex:158334] kallikrein:alpha2-macroglobulin [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:481007] Exocytosis of platelet alpha granule contents [Homo sapiens] [Reaction:9938539] kallikrein:kininogen:cell surface receptor -> kallikrein + cleaved kininogen:cell surface receptor + bradykinin [Homo sapiens] [Reaction:9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) [Homo sapiens] [Reaction:9655850] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst) [Homo sapiens] [Reaction:158311] OBSOLETE_kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin_REPLACEMENT_9938539 [Homo sapiens] [Reaction:158251] OBSOLETE_prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer_REPLACMENT_9857945 [Homo sapiens]
releaseDate	2005-04-11
reviewed	[InstanceEdit:9980333] Schmaier, Alvin H, 2026-01-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359330] R-HSA-158340.6
summation	[Summation:158348] Activated plasma kallikrein binds to alpha2-macroglobulin (S...
(hasEvent)	[Pathway:140837] OBSOLETE_Intrinsic Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9970672 [Homo sapiens] [Pathway:9855719] Regulation of FXIIa and plasma kallikrein activity [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9984719] Update Tracker - [Reaction:158340] kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin - v96:[modifyText]
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No pathways have been reviewed or authored by kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin (158340)