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Details on Person OBSOLETE_kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin_REPLACEMENT_9938539

Class:Id	Reaction:158311
_displayName	OBSOLETE_kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin_REPLACEMENT_9938539
_doRelease	FALSE
_timestamp	2026-01-20 07:26:41
authored	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
catalystActivity	[CatalystActivity:158359] serine-type endopeptidase activity of kallikrein:kininogen:C1q binding protein tetramer [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
input	[Complex:158197] kallikrein:kininogen:C1q binding protein tetramer [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:158381] Human high molecular weight kininogen. Studies of structure-function relationships and of proteolysis of the molecule occurring during contact activation of plasma. [LiteratureReference:158183] The amino acid sequence of the light chain of human high-molecular-mass kininogen [LiteratureReference:158413] Completion of the primary structure of human high-molecular-mass kininogen. The amino acid sequence of the entire heavy chain and evidence for its evolution by gene triplication. [LiteratureReference:158182] High molecular weight kininogen regulates prekallikrein assembly and activation on endothelial cells: a novel mechanism for contact activation
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:167229] D'Eustachio, P, 2005-10-13 14:50:40 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9979525] Shamovsky, Veronica, 2026-01-20
name	OBSOLETE_kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin_REPLACEMENT_9938539
output	[Complex:158140] Plasma kallikrein [extracellular region] [Homo sapiens] [Complex:158257] activated kininogen:C1q binding protein tetramer [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:158344] Bradykinin [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:158251] OBSOLETE_prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer_REPLACMENT_9857945 [Homo sapiens] [Reaction:158218] OBSOLETE_prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer_REPLACEMENT_9857939_9857952 [Homo sapiens]
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360460] R-HSA-158311.3
summation	[Summation:158393] The cleavage of kininogen (HK, high molecular weight kininog...
(hasEvent)	[Pathway:140837] OBSOLETE_Intrinsic Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9970672 [Homo sapiens] [Pathway:9855689] factor XIIa activates plasma kallikrein-kinin system [Homo sapiens] [Pathway:9970672] FXIIa activates plasma kallikrein-kinin system [Homo sapiens]
(precedingEvent)	[Reaction:158313] factor XII -> factor XIIa [Homo sapiens] [Reaction:158340] kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin [Homo sapiens] [Reaction:158399] kallikrein binds SERPING1 [Homo sapiens] [FailedReaction:9651467] SERPING1 variant does not bind kallikrein [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779006] Update Tracker - [Reaction:158311] kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin - v66:[modifyText]
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No pathways have been reviewed or authored by OBSOLETE_kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin_REPLACEMENT_9938539 (158311)