Query author contributions in Reactome

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Details on Person factor VIIIa [extracellular region]

Class:Id	Complex:158307
_displayName	factor VIIIa [extracellular region]
_timestamp	2008-06-20 12:49:21
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
hasComponent	[EntityWithAccessionedSequence:158290] F8(20-391) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:158199] F8(392-759) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:158271] F8(1709-2351) [extracellular region] [Homo sapiens]
name	factor VIIIa
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:366282] R-HSA-158307.1
(input)	[Reaction:5607002] Activated protein C cleaves factor VIIIa [Homo sapiens] [Reaction:5607043] factor VIIIa associates with cell membrane [Homo sapiens] [Reaction:9670014] Factor VIIIa dissociates [Homo sapiens]
(normalEntity)	[EntityFunctionalStatus:9670056] gain_of_function of factor VIIIa with defective A2 domain [extracellular region] [EntityFunctionalStatus:9670057] gain_of_function of factor VIIIa with defective A1 domain [extracellular region] [EntityFunctionalStatus:9670212] loss_of_function of FVIIIa variants [extracellular region]
(output)	[Reaction:158137] factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer [Homo sapiens] [Reaction:9822522] factor VIII -> factor VIIIa + factor VIII B chain+ factor VIII A3 acidic polypeptide +VWF multimer (TF:FVIIa:FXa catalyst) [Homo sapiens]
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No pathways have been reviewed or authored by factor VIIIa [extracellular region] (158307)