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Details on Person factor XIIa [extracellular region]

Class:Id	Complex:158306
_displayName	factor XIIa [extracellular region]
_timestamp	2024-01-09 12:16:54
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
hasComponent	[EntityWithAccessionedSequence:158285] factor XIIa heavy chain [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:158320] factor XIIa light chain [extracellular region] [Homo sapiens]
modified	[InstanceEdit:9857918] Shamovsky, Veronica, 2024-01-09
name	factor XIIa FXIIa
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:365383] R-HSA-158306.2
(activeUnit)	[CatalystActivity:9936902] serine-type endopeptidase activity of factor XII:β-amyloid fibril:Zn2+ [extracellular region]
(hasComponent)	[Complex:158141] factor XIIa:C1Inh [extracellular region] [Homo sapiens] [Complex:9653860] HRG:factor XIIa [extracellular region] [Homo sapiens]
(input)	[Reaction:158357] factor XIIa binds SERPING1 [Homo sapiens] [FailedReaction:9651456] SERPING1 variant does not bind factor XIIa [Homo sapiens] [Reaction:9653879] factor XIIa binds HRG [Homo sapiens] [Reaction:9655840] FXIIa is cleaved to β-FXIIa [Homo sapiens]
(output)	[Reaction:158313] factor XII -> factor XIIa [Homo sapiens] [Reaction:9855735] factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) [Homo sapiens] [Reaction:9857814] prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface) [Homo sapiens] [Reaction:9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) [Homo sapiens] [Reaction:9936906] factor XII:β-amyloid:Zn2+-> factor XIIa + β-amyloid:Zn2+ (autocatalysis) [Homo sapiens]
(physicalEntity)	[CatalystActivity:158386] serine-type endopeptidase activity of factor XIIa [extracellular region]
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No pathways have been reviewed or authored by factor XIIa [extracellular region] (158306)