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Details on Person factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)

Class:Id	Reaction:158300
_displayName	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
_doRelease	TRUE
_timestamp	2026-02-24 18:47:56
authored	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
catalystActivity	[CatalystActivity:158386] serine-type endopeptidase activity of factor XIIa [extracellular region]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
input	[Complex:158162] factor XI:GPIb-IX-V complex [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:9857836] A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo [LiteratureReference:158206] Human blood coagulation factor XI. Purification, properties, and mechanism of activation by activated factor XII. [LiteratureReference:158259] Activation of human factor XI (plasma thromboplastin antecedent) by factor XIIa (activated Hageman factor) [LiteratureReference:158171] Location of the disulfide bonds in human coagulation factor XI: the presence of tandem apple domains
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:352550] D'Eustachio, P, 2008-06-03 23:47:06 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9861372] D'Eustachio, Peter, 2024-02-17 [InstanceEdit:9935717] Shamovsky, Veronica, 2025-01-18 [InstanceEdit:9979524] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9983442] Shamovsky, Veronica, 2026-02-24
name	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)
output	[Complex:158130] factor XIa:GPIb:GPIX:GPV complex [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:158313] factor XII -> factor XIIa [Homo sapiens] [Reaction:158311] OBSOLETE_kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin_REPLACEMENT_9938539 [Homo sapiens] [Reaction:9655850] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst) [Homo sapiens] [Reaction:9857945] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (PRCP catalyst) [Homo sapiens] [Reaction:158145] factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex [Homo sapiens] [Reaction:9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) [Homo sapiens] [Reaction:9909048] prekallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor:factor XII (FXII catalyst) [Homo sapiens] [Reaction:9857814] prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface) [Homo sapiens] [Reaction:9855685] factor XII + prekallikrein:kininogen:cell surface receptor -> prekallikrein:kininogen:cell surface receptor:factor XII [Homo sapiens] [Reaction:9855735] factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) [Homo sapiens] [Reaction:9855705] factor XII + polyanionic activator -> factor XII:polyanionic activator (in plasma) [Homo sapiens]
releaseDate	2005-04-11
reviewed	[InstanceEdit:9980333] Schmaier, Alvin H, 2026-01-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361733] R-HSA-158300.6
summation	[Summation:158329] Factor XI, bound to the cell surface, is converted to activa...
(hasEvent)	[Pathway:140837] OBSOLETE_Intrinsic Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9970672 [Homo sapiens] [Pathway:9935598] FXIIa, PKa-dependent activation of coagulation pathway [Homo sapiens]
(precedingEvent)	[Reaction:158333] factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) [Homo sapiens] [Reaction:9653838] factor XIa binds SERPING1 [Homo sapiens] [Reaction:9655851] factor XIa binds SERPINE1 [Homo sapiens] [Reaction:9657706] factor XIa binds APP(18-770) [Homo sapiens] [Reaction:9936467] factor IX -> factor IXa + factor IX activation peptide (kallikrein catalyst) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780866] Update Tracker - [Reaction:158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) - v62:[modifyText] [_UpdateTracker:9864117] Update Tracker - [Reaction:158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) - v88:[modifyText, removeLiteratureReference] [_UpdateTracker:9939821] Update Tracker - [Reaction:158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) - v92:[modifyText, removeLiteratureReference] [_UpdateTracker:9984613] Update Tracker - [Reaction:158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) - v96:[modifyText]
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No pathways have been reviewed or authored by factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (158300)