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Details on Person SERPING1 [extracellular region]

Class:Id	EntityWithAccessionedSequence:158296
_displayName	SERPING1 [extracellular region]
_timestamp	2016-01-18 16:29:24
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
endCoordinate	500
modified	[InstanceEdit:3209923] Jassal, B, 2013-03-04 [InstanceEdit:8852474] Jupe, Steve, 2016-01-18
name	SERPING1 C1Inh plasma protease C1 inhibitor C1-In
referenceEntity	[ReferenceGeneProduct:57002] UniProt:P05155 SERPING1 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:370990] R-HSA-158296.2
startCoordinate	23
(hasComponent)	[Complex:158141] factor XIIa:C1Inh [extracellular region] [Homo sapiens] [Complex:158423] kallikrein:C1Inh [extracellular region] [Homo sapiens] [Complex:8852475] 2x Activated C1S:2x Activated C1R:4xSERPING1 [extracellular region] [Homo sapiens] [Complex:8959916] Antigen:IgG:C1Q:2xActivated C1R:2xActivated C1S [plasma membrane] [Homo sapiens] [Complex:8959917] Activated C1S:SERPING1 [extracellular region] [Homo sapiens] [Complex:8959919] Activated C1R:SERPING1 [extracellular region] [Homo sapiens] [Complex:9653851] SERPING1:factor XIa:GPIb:GPIX:GPV [plasma membrane] [Homo sapiens]
(hasMember)	[DefinedSet:481033] Platelet alpha granule contents [extracellular region] [Homo sapiens]
(input)	[Reaction:158357] factor XIIa binds SERPING1 [Homo sapiens] [Reaction:158399] kallikrein binds SERPING1 [Homo sapiens] [Reaction:8852266] C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s [Homo sapiens] [Reaction:9653838] factor XIa binds SERPING1 [Homo sapiens]
(normalEntity)	[EntityFunctionalStatus:9650320] loss_of_function of HAE type 2-causing SERPING1 variants [extracellular region]
(output)	[BlackBoxEvent:9650473] SERPING1 is secreted [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9887054] Update Tracker - [EntityWithAccessionedSequence:158296] SERPING1 [extracellular region] - v45:[addName] [_UpdateTracker:9893505] Update Tracker - [EntityWithAccessionedSequence:158296] SERPING1 [extracellular region] - v56:[addName]
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No pathways have been reviewed or authored by SERPING1 [extracellular region] (158296)