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Details on Person Mature factor IX (FIX) is secreted and circulates in the pla...
| Class:Id | Summation:158246 |
|---|---|
| _displayName | Mature factor IX (FIX) is secreted and circulates in the pla... |
| _timestamp | 2025-02-18 10:20:03 |
| created | [InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36 |
| literatureReference | [LiteratureReference:158184] Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential [LiteratureReference:158295] Human blood coagulation factor IX. Purification, properties, and mechanism of activation by activated factor XI. [LiteratureReference:9670704] Activation of human factor IX (Christmas factor) [LiteratureReference:9672417] Structural basis of the cofactor- and substrate-assisted activation of human coagulation factor IXa [LiteratureReference:9671235] A sequential mechanism for exosite-mediated factor IX activation by factor XIa [LiteratureReference:9673271] Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIa [LiteratureReference:9653842] The mechanism underlying activation of factor IX by factor XIa [LiteratureReference:9673274] Hydrogen-deuterium exchange mass spectrometry highlights conformational changes induced by factor XI activation and binding of factor IX to factor XIa [LiteratureReference:9673243] Characterization of Novel Forms of Coagulation Factor XIa: independence of factor XIa subunits in factor IX activation [LiteratureReference:9673211] Factor IX activation by factor XIa proceeds without release of a free intermediate [LiteratureReference:9653848] An update on factor XI structure and function [LiteratureReference:9673475] Sodium-site in serine protease domain of human coagulation factor IXa: evidence from the crystal structure and molecular dynamics simulations study |
| modified | [InstanceEdit:9673276] Shamovsky, Veronica, 2020-01-07 [InstanceEdit:9673476] Shamovsky, Veronica, 2020-01-07 [InstanceEdit:9674491] Shamovsky, Veronica, 2020-01-13 [InstanceEdit:9935024] Shamovsky, Veronica, 2025-01-12 [InstanceEdit:9938585] Shamovsky, Veronica, 2025-02-18 |
| text | Mature factor IX (FIX) is secreted and circulates in the plasma as an inactive 57kDa zymogen form F9(47-461). Activation of FIX involves cleavage of two peptide bonds, at arginine 191 (R191-A192, the α-cleavage) and at arginine 226 (R226-V227, the β-cleavage), releasing an activation peptide (A192-R226) (Di Scipio RG et al. 1978; Zögg T & Brandstetter H 2009). The activation peptide has no known function. During the amplification phase of coagulation, this calcium-dependent reaction is catalyzed by factor XIa (FXIa), bound to platelet glycoprotein (GP) Ib:IX:V on the platelet cell surface (Osterud B et al. 1978; Gailani D et al. 2001; Geng Y et al. 2012). Structural studies suggest that both activation of factor XI and binding it to FIX induce conformational changes at the interface between the catalytic and the apple domains of the activated FXIa. The conformational changes of FXIa increase the accessibility to the apple 3 (A3) domain to enable FIX binding (Geng Y et al. 2012; Bar Barroeta A et al. 2019). FIX activation is ordered. FIX first binds to the FXIa A3 domain followed by engagement at the protease active site and cleavage of the R191-Al192 bond (Geng Y et al. 2012, 2013; Gailani D et al. 2014). The cleavage after R191 facilitates cleavage of the R226-V227 bond, forming the activated FIXa (also known as factor IXaβ). Catalytic efficiency for the second cleavage by FXIa is 7-fold greater than for the first cleavage, explaining the low accumulation of the α-cleavage product of FIX (Wolberg AS et al. 1997; Smith SB et al. 2008; Geng Y et al. 2012; Mohammed BM et al. 2018). Activated FIXa comprises an N-terminal light chain and a C-terminal heavy chain held together by a disulphide bridge between cysteine resides 178 and 335 (Di Scipio RG et al. 1978; Zögg T & Brandstetter H 2009). The X-ray structure of the FIXa EGF2/protease domain at 1.37 A revealed that a Na+-binding site in association with Ca²⁺-binding site contributed to stabilization of the FIXa protease domain (Vadivel K et al. 2019). |
| (summation) | [Reaction:158333] factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) [Homo sapiens] |
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