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Details on Person Activated plasma kallikrein binds to the plasma protease C1 ...

Class:IdSummation:158236
_displayNameActivated plasma kallikrein binds to the plasma protease C1 ...
_timestamp2026-03-04 06:22:50
created[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
literatureReference[LiteratureReference:158222] Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization
[LiteratureReference:158405] Distribution of plasma kallikrein between C-1 inactivator and alpha 2-macroglobulin in plasma utilizing a new assay for alpha 2-macroglobulin-kallikrein complexes
[LiteratureReference:158369] The inhibition of plasmin, plasma kallikrein, plasma permeability factor, and the C'1r subcomponent of the first component of complement by serum C'1 esterase inhibitor
[LiteratureReference:9983509] Protection of human plasma kallikrein from inactivation by C1 inhibitor and other protease inhibitors. The role of high molecular weight kininogen
modified[InstanceEdit:167229] D'Eustachio, P, 2005-10-13 14:50:40
[InstanceEdit:9674480] Shamovsky, Veronica, 2020-01-13
[InstanceEdit:9983511] Shamovsky, Veronica, 2026-02-24
[InstanceEdit:9983929] Shamovsky, Veronica, 2026-03-02
[InstanceEdit:9984159] Shamovsky, Veronica, 2026-03-04
textActivated plasma kallikrein binds to the plasma protease C1 inhibitor (C1INH, encoded by the SERPING1 gene) (Bock SC et al., 1986), forming a stable and enzymatically inactive complex. This reaction appears to be the major means by which plasma kallikrein is inactivated (plasma kallikrein can also be inactivated by binding to α2-macroglobulin) (Harpel PC et al., 1985; Ratnoff OD et al,. 1969; Schapira M et al., 1981). The relative contributions of C1INH and α2-macroglobulin to kallikrein inhibition vary among studies (Schapira M et al., 1981; Harpel PC et al., 1985).
(summation)[Reaction:158399] kallikrein binds SERPING1 [Homo sapiens]
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