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Details on Person OBSOLETE_prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer_REPLACEMENT_9857939_9857952

Class:Id	Reaction:158218
_displayName	OBSOLETE_prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer_REPLACEMENT_9857939_9857952
_doRelease	FALSE
_timestamp	2026-01-20 07:27:09
authored	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
input	[EntityWithAccessionedSequence:158385] KLKB1(20-638) [plasma membrane] [Homo sapiens] [Complex:158172] KNG:C1q binding protein tetramer [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:158187] High molecular weight kininogen peptides inhibit the formation of kallikrein on endothelial cell surfaces and subsequent urokinase-dependent plasmin formation [LiteratureReference:158116] The relative priority of prekallikrein and factors XI/XIa assembly on cultured endothelial cells [LiteratureReference:158182] High molecular weight kininogen regulates prekallikrein assembly and activation on endothelial cells: a novel mechanism for contact activation [LiteratureReference:158228] Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:167229] D'Eustachio, P, 2005-10-13 14:50:40 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9979527] Shamovsky, Veronica, 2026-01-20
name	OBSOLETE_prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer_REPLACEMENT_9857939_9857952
output	[Complex:158404] prekallikrein:kininogen:C1q binding protein tetramer [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:158354] OBSOLETE_kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer_REPLACEMENT_9857939_9857952 [Homo sapiens] [Reaction:481007] Exocytosis of platelet alpha granule contents [Homo sapiens]
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359127] R-HSA-158218.3
summation	[Summation:158244] Prekallikrein (PK) associates specifically with kininogen (H...
(hasEvent)	[Pathway:140837] OBSOLETE_Intrinsic Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9970672 [Homo sapiens] [Pathway:9855689] factor XIIa activates plasma kallikrein-kinin system [Homo sapiens] [Pathway:9970672] FXIIa activates plasma kallikrein-kinin system [Homo sapiens]
(precedingEvent)	[Reaction:158251] OBSOLETE_prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer_REPLACMENT_9857945 [Homo sapiens]
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No pathways have been reviewed or authored by OBSOLETE_prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer_REPLACEMENT_9857939_9857952 (158218)