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Details on Person factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex

Class:Id	Reaction:158145
_displayName	factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex
_doRelease	TRUE
_timestamp	2025-01-12 02:04:59
authored	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
input	[Complex:158234] factor XI [extracellular region] [Homo sapiens] [Complex:114668] GPIb-IX-V [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:158342] Binding of coagulation factor XI to washed human platelets [LiteratureReference:9860375] Identification of a binding site for glycoprotein Ibalpha in the Apple 3 domain of factor XI [LiteratureReference:9860379] Role of platelets in regulating activated coagulation factor XI activity [LiteratureReference:9653848] An update on factor XI structure and function
modified	[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:352556] D'Eustachio, P, 2008-06-03 23:48:33 [InstanceEdit:352623] D'Eustachio, P, 2008-06-04 14:37:31 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:3211653] Jupe, S, 2013-03-08 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9860377] Shamovsky, Veronica, 2024-02-05 [InstanceEdit:9934231] Shamovsky, Veronica, 2025-01-07 [InstanceEdit:9935049] Shamovsky, Veronica, 2025-01-12
name	factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex
output	[Complex:158162] factor XI:GPIb-IX-V complex [plasma membrane] [Homo sapiens]
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361087] R-HSA-158145.5
summation	[Summation:158345] This Reactome event describes factor XI (FXI) binding to the...
(hasEvent)	[Pathway:140837] OBSOLETE_Intrinsic Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9970672 [Homo sapiens] [Pathway:9769743] Amplification and propagation of coagulation cascade [Homo sapiens]
(precedingEvent)	[Reaction:158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) [Homo sapiens] [Reaction:158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) [Homo sapiens]
(replacementInstances)	[_Deleted:352551] Deletion of instance: 158261
(updatedInstance)	[_UpdateTracker:9787436] Update Tracker - [Reaction:158145] factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex - v45:[add_removeInput] [_UpdateTracker:9791877] Update Tracker - [Reaction:158145] factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex - v25:[modifyText, removeLiteratureReference, removeRegulator] [_UpdateTracker:9864149] Update Tracker - [Reaction:158145] factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex - v88:[add_removeLiteratureReference, modifyText] [_UpdateTracker:9939835] Update Tracker - [Reaction:158145] factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex - v92:[add_removeLiteratureReference, modifyText]
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No pathways have been reviewed or authored by factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (158145)