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Details on Person factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer

Class:IdReaction:158118
_displayNamefactor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer
_doReleaseTRUE
_timestamp2025-01-08 19:25:01
authored[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
compartment[Compartment:984] extracellular region
created[InstanceEdit:158298] D'Eustachio, P, 2005-01-20 14:44:36
edited[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
input[Complex:158350] factor VIII [extracellular region] [Homo sapiens]
[Complex:158136] VWF multimer [extracellular region] [Homo sapiens]
literatureReference[LiteratureReference:158205] The affinity and stoichiometry of binding of human factor VIII to von Willebrand factor
[LiteratureReference:158420] Differential proteolytic activation of factor VIII-von Willebrand factor complex by thrombin
[LiteratureReference:158352] Association of the factor VIII light chain with von Willebrand factor
[LiteratureReference:9668008] Visualization of an N-terminal fragment of von Willebrand factor in complex with factor VIII
[LiteratureReference:9661680] Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry
[LiteratureReference:9667090] Interaction Between the a3 Region of Factor VIII and the TIL'E' Domains of the von Willebrand Factor
[LiteratureReference:158401] Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity.
[LiteratureReference:158117] Amino acid sequence of human von Willebrand factor
[LiteratureReference:158273] Structure of human factor VIII
modified[InstanceEdit:158647] D'Eustachio, P, 2005-02-03 20:03:59
[InstanceEdit:158649] D'Eustachio, P, 2005-02-03 20:12:12
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9670709] Shamovsky, Veronica, 2019-12-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9934477] Shamovsky, Veronica, 2025-01-08
namefactor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer
output[Complex:158363] factor VIII:von Willebrand factor multimer [extracellular region] [Homo sapiens]
precedingEvent
releaseDate2005-04-11
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361974] R-HSA-158118.5
summation[Summation:158266] Factor VIII (FVIII) binds to von Willebrand factor (vWF) to ...
(hasEvent)[Pathway:140837] OBSOLETE_Intrinsic Pathway of Fibrin Clot Formation_REPLACEMENT_9769743_9970672 [Homo sapiens]
[Pathway:9769743] Amplification and propagation of coagulation cascade [Homo sapiens]
(normalReaction)[FailedReaction:9665809] F8 variant does not bind von Willebrand factor [Homo sapiens]
(precedingEvent)[Reaction:158137] factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer [Homo sapiens]
[FailedReaction:9666383] F8 variant is not cleaved by thrombin [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777359] Update Tracker - [Reaction:158118] factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer - v72:[modifyText]
[_UpdateTracker:9777483] Update Tracker - [Reaction:158118] factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer - v71:[modifyText]
[_UpdateTracker:9846763] Update Tracker - [Reaction:158118] factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer - v84:[modifyText]
[_UpdateTracker:9939710] Update Tracker - [Reaction:158118] factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer - v92:[modifyText, removeLiteratureReference]
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No pathways have been reviewed or authored by factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (158118)
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