Query author contributions in Reactome
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Details on Person Activated p21ras (the GTP-bound form) is associated with the...
| Class:Id | Summation:157822 |
|---|---|
| _displayName | Activated p21ras (the GTP-bound form) is associated with the... |
| _timestamp | 2006-10-17 11:05:05 |
| created | [InstanceEdit:157820] Charalambous, M, 2005-01-07 11:17:43 |
| modified | [InstanceEdit:157835] Schmidt, EE, 2005-01-07 14:38:14 [InstanceEdit:188528] Jassal, B, 2006-10-17 11:04:33 |
| text | Activated p21ras (the GTP-bound form) is associated with the plasma membrane. Inactive Raf-1 is associated in the cytoplasm with 14-3-3. 14-3-3 binds to Raf-1 via the Ser259 phosphorylation site (S1). This interaction stabilises the inactive conformation of Raf-1 in which the Ras-binding Cysteine-rich domain (CRD) is obscured. The Raf-1 molecule contains an additional p21ras-binding domain (RBD), a second serine phosphorylation site at S621 (S2) and two tyrosine phosphorylation sites (at 340, Y1 and 341, Y2). Raf-1 binds activated p21ras via the RBD. This displaces 14-3-3 from Ser259 and unmasks the CRD. |
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No pathways have been reviewed or authored by Activated p21ras (the GTP-bound form) is associated with the... (157822)
