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Details on Person UniProt:Q9BW27 NUP85

Class:Id	ReferenceGeneProduct:157704
_chainChangeLog	chain:1-656 added on Sat February 7 2015
_displayName	UniProt:Q9BW27 NUP85
_timestamp	2024-11-03 19:37:53
chain	chain:1-656
checksum	1AE2BA17D9CADF3D
comment	FUNCTION Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (PubMed:12718872). As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus (PubMed:12718872). The Nup107-160 complex seems to be required for spindle assembly during mitosis (PubMed:16807356). NUP85 is required for membrane clustering of CCL2-activated CCR2 (PubMed:15995708). Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade (PubMed:15995708). Involved in nephrogenesis (PubMed:30179222).SUBUNIT Component of the nuclear pore complex (NPC) (PubMed:12196509). Component of the NPC Nup107-160 subcomplex, consisting of at least NUP107, NUP98/Nup96, NUP160, NUP133, NUP85, NUP37, NUP43 and SEC13 (PubMed:15146057). Interacts with NUP160, NUP133 and SEC13 (PubMed:12718872, PubMed:30179222). Interacts with NUP37, NUP107 and NUP43 (PubMed:15146057). Interacts with CCR2 (PubMed:15995708).INTERACTION During mitosis, localizes to the kinetochores and spindle poles (PubMed:12718872, PubMed:16807356). Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells (PubMed:15995708).ALTERNATIVE PRODUCTS The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the nucleoporin Nup85 family.SEQUENCE CAUTION Truncated N-terminus.
created	[InstanceEdit:157706] Gillespie, ME, 2005-01-05 21:25:13
description	recommendedName: Nuclear pore complex protein Nup85 alternativeName: 85 kDa nucleoporin alternativeName: FROUNT alternativeName: Nucleoporin Nup75 alternativeName: Nucleoporin Nup85 alternativeName: Pericentrin-1
geneName	NUP85 NUP75 PCNT1
identifier	Q9BW27
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Centromere Chromosome Cytoplasm Cytoskeleton Disease variant Kinetochore Membrane mRNA transport Nuclear pore complex Nucleus Phosphoprotein Protein transport Proteomics identification Reference proteome Translocation Transport
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	NUP85
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8990287] ENSEMBL:ENSG00000125450 NUP85 [Homo sapiens]
secondaryIdentifier	NUP85_HUMAN B4DMQ3 B4DPW1 Q8NDI4 Q9H9U1
sequenceLength	656
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8973388] UniProt:Q9BW27-1 NUP85 [Homo sapiens] [ReferenceIsoform:8973389] UniProt:Q9BW27-2 NUP85 [Homo sapiens] [ReferenceIsoform:8973390] UniProt:Q9BW27-3 NUP85 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:157741] NUP85 [nuclear envelope] [Homo sapiens] [EntityWithAccessionedSequence:376238] NUP85 [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q9BW27 NUP85 (157704)