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Details on Person UniProt:O15504 NUP42
| Class:Id | ReferenceGeneProduct:157693 |
|---|---|
| _chainChangeLog | chain:1-423 added on Fri February 6 2015 |
| _displayName | UniProt:O15504 NUP42 |
| _timestamp | 2024-11-03 20:11:06 |
| chain | chain:1-423 |
| checksum | 6F8B95073312E999 |
| comment | FUNCTION Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.FUNCTION (Microbial infection) In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope.SUBUNIT Probable component of the nuclear pore complex (NPC). Interacts with nuclear export protein NXF1 (PubMed:10228171). Interacts with GLE1. Able to form a heterotrimer with NUP155 and GLE1 in vitro (PubMed:16000379). Interacts with XPO1 (PubMed:10358091).SUBUNIT (Microbial infection) Interacts with the HIV-1 virus proteins Rev and Vpr. The interaction with HIV-1 Rev, a protein that mediates nuclear export of unspliced viral RNAs, suggests that its function may be bypassed by the HIV-1 virus.INTERACTION Excluded from the nucleolus.ALTERNATIVE PRODUCTS Ubiquitously expressed.DOMAIN The FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC.PTM O-glycosylated. |
| created | [InstanceEdit:157706] Gillespie, ME, 2005-01-05 21:25:13 |
| description | recommendedName: fullName evidence="12"Nucleoporin NUP42 alternativeName: NLP-1 alternativeName: NUP42 homolog alternativeName: Nucleoporin hCG1 alternativeName: fullName evidence="13"Nucleoporin-42 alternativeName: Nucleoporin-like protein 2 |
| geneName | NUP42 CG1 NUPL2 |
| identifier | O15504 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Glycoprotein Membrane Metal-binding mRNA transport Nuclear pore complex Nucleus Phosphoprotein Protein transport Proteomics identification Reference proteome Repeat Translocation Transport Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NUP42 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994390] ENSEMBL:ENSG00000136243 NUP42 [Homo sapiens] |
| secondaryIdentifier | NUP42_HUMAN A4D143 B4DP42 Q49AE7 Q9BS49 |
| sequenceLength | 423 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:240792] UniProt:O15504-2 NUP42 [Homo sapiens] [ReferenceIsoform:240793] UniProt:O15504-3 NUP42 [Homo sapiens] [ReferenceIsoform:401349] UniProt:O15504-1 NUP42 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:157697] NUPL2 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O15504 NUP42 (157693)
