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Details on Person NEXT2 is cleaved to produce NICD2

Class:IdReaction:157640
_displayNameNEXT2 is cleaved to produce NICD2
_doReleaseTRUE
_timestamp2017-07-24 15:16:53
authored[InstanceEdit:157021] Jassal, B, 2004-12-15 13:08:03
catalystActivity[CatalystActivity:157355] aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:157354] Jassal, B, 2004-12-21 14:32:26
edited[InstanceEdit:3159303] Haw, R, 2013-01-14
inferredFrom
input[EntityWithAccessionedSequence:157225] NEXT2 [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:2197549] Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis
[LiteratureReference:163904] A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
[LiteratureReference:163911] Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
[LiteratureReference:157796] Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling
[LiteratureReference:9013285] Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins
modified[InstanceEdit:157946] Jassal, B, 2005-01-10 12:51:46
[InstanceEdit:163921] Jassal, B, 2005-05-10 09:02:53
[InstanceEdit:164592] Wu, G, 2005-06-02 14:44:47
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:2122963] Orlic-Milacic, M, 2012-02-14
[InstanceEdit:2197565] Orlic-Milacic, M, 2012-04-12
[InstanceEdit:2978083] Orlic-Milacic, M, 2013-01-10
[InstanceEdit:3446783] Orlic-Milacic, M, 2013-05-15
[InstanceEdit:3446784] Orlic-Milacic, M, 2013-05-15
[InstanceEdit:3448658] Orlic-Milacic, M, 2013-05-15
[InstanceEdit:3451015] Orlic-Milacic, M, 2013-05-16
[InstanceEdit:9013403] Orlic-Milacic, Marija, 2017-07-24
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameNEXT2 is cleaved to produce NICD2
output[EntityWithAccessionedSequence:157642] NICD2 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:157628] NOTCH2(1666-1696) [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2013-06-11
reviewed[InstanceEdit:3448657] Boyle, Scott, 2013-04-25
[InstanceEdit:3448655] Ilagan, Ma Xenia, 2013-04-25
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:2980678] Orlic-Milacic, M, 2013-01-11
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360703] R-HSA-157640.3
summation[Summation:178971] NEXT2 fragment of NOTCH2 is further cleaved at the S3 site b...
(hasEvent)[Pathway:2979096] NOTCH2 Activation and Transmission of Signal to the Nucleus [Homo sapiens]
(precedingEvent)[Reaction:157933] NICD2 traffics to the nucleus [Homo sapiens]
(updatedInstance)[_UpdateTracker:9780648] Update Tracker - [Reaction:157640] NEXT2 is cleaved to produce NICD2 - v62:[addLiteratureReference]
[_UpdateTracker:9787829] Update Tracker - [Reaction:157640] NEXT2 is cleaved to produce NICD2 - v44:[modifyText]
[_UpdateTracker:9788568] Update Tracker - [Reaction:157640] NEXT2 is cleaved to produce NICD2 - v41:[addLiteratureReference]
[_UpdateTracker:9789153] Update Tracker - [Reaction:157640] NEXT2 is cleaved to produce NICD2 - v38:[modifyText]
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