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Details on Person aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]

Class:Id	CatalystActivity:157355
_displayName	aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
_timestamp	2017-07-24 14:18:17
activeUnit	[DefinedSet:9013333] Presenilin [plasma membrane] [Homo sapiens]
activity	[GO_MolecularFunction:1933] aspartic-type endopeptidase activity
created	[InstanceEdit:157354] Jassal, B, 2004-12-21 14:32:26
modified	[InstanceEdit:9013363] Orlic-Milacic, Marija, 2017-07-24 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9658105] Weiser, JD, 2019-08-09 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9666277] Weiser, JD, 2019-11-04 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9676538] Cook, Justin, 2020-02-17 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9689079] Cook, Justin, 2020-05-15 [InstanceEdit:9715688] Shorser, Solomon, 2021-02-17 [InstanceEdit:9715688] Shorser, Solomon, 2021-02-17 [InstanceEdit:9729976] Shorser, Solomon, 2021-05-05 [InstanceEdit:9729976] Shorser, Solomon, 2021-05-05 [InstanceEdit:9750461] Weiser, JD, 2021-08-11 [InstanceEdit:9750461] Weiser, JD, 2021-08-11 [InstanceEdit:9757984] Weiser, JD, 2021-11-08 [InstanceEdit:9757984] Weiser, JD, 2021-11-08 [InstanceEdit:9767390] Wright, Adam, 2022-02-25 [InstanceEdit:9767390] Wright, Adam, 2022-02-25 [InstanceEdit:9773515] Weiser, Joel, 2022-05-04 [InstanceEdit:9773515] Weiser, Joel, 2022-05-04 [InstanceEdit:9909910] Weiser, Joel, 2024-05-14 [InstanceEdit:9909910] Weiser, Joel, 2024-05-14 [InstanceEdit:9917728] Weiser, Joel, 2024-08-09 [InstanceEdit:9917728] Weiser, Joel, 2024-08-09 [InstanceEdit:9926726] Weiser, Joel, 2024-11-03 [InstanceEdit:9926726] Weiser, Joel, 2024-11-03 [InstanceEdit:9939161] Weiser, Joel, 2025-02-21 [InstanceEdit:9939161] Weiser, Joel, 2025-02-21 [InstanceEdit:9948552] Weiser, Joel, 2025-05-21 [InstanceEdit:9948552] Weiser, Joel, 2025-05-21 [InstanceEdit:9963749] Weiser, Joel, 2025-08-15 [InstanceEdit:9963749] Weiser, Joel, 2025-08-15 [InstanceEdit:9970792] Weiser, Joel, 2025-10-31 [InstanceEdit:9970792] Weiser, Joel, 2025-10-31 [InstanceEdit:9983308] Weiser, Joel, 2026-02-22 [InstanceEdit:9983308] Weiser, Joel, 2026-02-22 [InstanceEdit:9989150] Weiser, Joel, 2026-05-15 [InstanceEdit:9989150] Weiser, Joel, 2026-05-15
physicalEntity	[Complex:157343] gamma-secretase complex [plasma membrane] [Homo sapiens]
(catalystActivity)	[Reaction:157353] NEXT1 is cleaved to produce NICD1 [Homo sapiens] [Reaction:157640] NEXT2 is cleaved to produce NICD2 [Homo sapiens] [Reaction:2197556] Gamma-secretase complex cleaves mNEXT2 [Homo sapiens] [Reaction:2220988] NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants [Homo sapiens] [Reaction:9013361] NEXT3 is cleaved to produce NICD3 [Homo sapiens] [BlackBoxEvent:9017817] Gamma-secretase cleaves YBX1:NOTCH3 [Homo sapiens] [Reaction:9604294] Gamma-secretase cleaves NOTCH4 [Homo sapiens] [Reaction:9604300] Gamma-secretase cleaves Notch4 [Homo sapiens] [Reaction:9980918] Gamma-secretase cleaves NEXT1 yielding NICD1 [Homo sapiens]
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No pathways have been reviewed or authored by aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane] (157355)