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Details on Person gamma-secretase complex [plasma membrane]

Class:Id	Complex:157343
_displayName	gamma-secretase complex [plasma membrane]
_timestamp	2017-07-24 14:12:33
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:157330] Jassal, B, 2004-12-21 13:25:45
hasComponent	[EntityWithAccessionedSequence:157331] PSENEN [plasma membrane] [Homo sapiens] [DefinedSet:157341] APH-1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:2534241] NCSTN [plasma membrane] [Homo sapiens] [DefinedSet:9013333] Presenilin [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:9013342] Therapeutic modulation of Notch signalling--are we there yet?
modified	[InstanceEdit:157354] Jassal, B, 2004-12-21 14:32:26 [InstanceEdit:3006798] Jupe, S, 2013-02-01 [InstanceEdit:9013349] Orlic-Milacic, Marija, 2017-07-24 [InstanceEdit:9013357] Orlic-Milacic, Marija, 2017-07-24
name	gamma-secretase complex
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:364032] R-HSA-157343.2
(hasComponent)	[Complex:2903165] Gamma-Secretase:GSIs [plasma membrane] [Homo sapiens]
(input)	[Reaction:2903169] GSIs bind gamma-secretase complex [Homo sapiens]
(physicalEntity)	[PhysicalEntityCellType:9980888] gamma-secretase complex [plasma membrane] in endothelial stalk cell [CatalystActivity:157355] aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane] [CatalystActivity:194541] endopeptidase activity of gamma-secretase complex [plasma membrane] [CatalystActivity:205109] peptidase activity of gamma-secretase complex [plasma membrane]
(regulator)	[PositiveRegulation:1980110] Positive regulation by 'gamma-secretase complex [plasma membrane]' [PositiveRegulation:1980114] Positive regulation by 'gamma-secretase complex [plasma membrane]' [PositiveRegulation:2974728] Positive regulation by 'gamma-secretase complex [plasma membrane]'
(updatedInstance)	[_UpdateTracker:9866478] Update Tracker - [Complex:157343] gamma-secretase complex [plasma membrane] - v22:[updateContainedComponent] [_UpdateTracker:9875370] Update Tracker - [Complex:157343] gamma-secretase complex [plasma membrane] - v44:[add_removeHasComponent, updateContainedComponent] [_UpdateTracker:9883727] Update Tracker - [Complex:157343] gamma-secretase complex [plasma membrane] - v45:[updateContainedComponent] [_UpdateTracker:9897758] Update Tracker - [Complex:157343] gamma-secretase complex [plasma membrane] - v62:[addLiteratureReference, add_removeHasComponent]
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No pathways have been reviewed or authored by gamma-secretase complex [plasma membrane] (157343)