Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person NEXT1 [plasma membrane]

Class:IdEntityWithAccessionedSequence:157200
_displayNameNEXT1 [plasma membrane]
_timestamp2013-05-09 15:03:36
compartment[Compartment:876] plasma membrane
created[InstanceEdit:157219] Jassal, B, 2004-12-17 11:53:55
endCoordinate2555
modified[InstanceEdit:1460331] Orlic-Milacic, M, 2011-07-26
[InstanceEdit:2193052] Orlic-Milacic, M, 2012-04-11
[InstanceEdit:3322333] Wu, G, 2013-05-03
[InstanceEdit:3322334] Wu, G, 2013-05-03
[InstanceEdit:3325515] Orlic-Milacic, M, 2013-05-09
nameNEXT1
NOTCH1(1721-2555)
Notch1 NEXT fragment
referenceEntity[ReferenceGeneProduct:60520] UniProt:P46531 NOTCH1 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:368454] R-HSA-157200.1
startCoordinate1721
(hasMember)[DefinedSet:1980036] NEXT [plasma membrane] [Homo sapiens]
(input)[Reaction:157353] NEXT1 is cleaved to produce NICD1 [Homo sapiens]
[Reaction:9980918] Gamma-secretase cleaves NEXT1 yielding NICD1 [Homo sapiens]
(normalEntity)[EntityFunctionalStatus:2775816] gain_of_function of NEXT1 PEST domain mutants [plasma membrane]
(output)[Reaction:157632] Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 [Homo sapiens]
[Reaction:1980119] Cleavage of TAN1 to produce NEXT1 [Homo sapiens]
[Reaction:1980134] NOTCH1:DLL/JAG complex is cleaved to produce NEXT1 [Homo sapiens]
[Reaction:2220968] NOTCH1 HD mutants and NOTCH1 t(7;9)(q34;q34.3) translocation mutant are cleaved by ADAM10/17 [Homo sapiens]
[Reaction:2666278] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1 [Homo sapiens]
[Reaction:2730752] NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding [Homo sapiens]
[Reaction:9980928] ADAM10 cleaves NOTCH1 [Homo sapiens]
(physicalEntity)[PhysicalEntityCellType:9980905] NEXT1 [plasma membrane] in endothelial stalk cell
(updatedInstance)[_UpdateTracker:9870814] Update Tracker - [EntityWithAccessionedSequence:157200] NEXT1 [plasma membrane] - v38:[addName]
[_UpdateTracker:9871737] Update Tracker - [EntityWithAccessionedSequence:157200] NEXT1 [plasma membrane] - v41:[modifyEndCoordinate, modifyStartCoordinate]
[_UpdateTracker:9881964] Update Tracker - [EntityWithAccessionedSequence:157200] NEXT1 [plasma membrane] - v45:[modifyName]
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No pathways have been reviewed or authored by NEXT1 [plasma membrane] (157200)