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Details on Person activated thrombin (factor IIa) [extracellular region]

Class:Id	Complex:156786
_displayName	activated thrombin (factor IIa) [extracellular region]
_timestamp	2023-11-17 05:20:35
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:156785] D'Eustachio, P, 2004-12-10 21:49:41
hasComponent	[EntityWithAccessionedSequence:140589] F2(364-622) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:140598] F2(315-363) [extracellular region] [Homo sapiens] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region] [SimpleEntity:74112] Ca2+ [extracellular region]
modified	[InstanceEdit:791496] Jupe, S, 2010-05-24 [InstanceEdit:5578882] Jupe, Steve, 2014-06-04 [InstanceEdit:9853559] Shamovsky, Veronica, 2023-11-17
name	activated thrombin (factor IIa) FIIa
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:366178] R-HSA-156786.2
(hasComponent)	[Complex:140874] thrombin:cleaved SERPINC1 [extracellular region] [Homo sapiens] [Complex:389470] Thrombin:Proteinase-activated receptors [plasma membrane] [Homo sapiens] [Complex:429532] GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] [Homo sapiens] [Complex:5578881] activated thrombin (factor IIa):SERPIND1 [extracellular region] [Homo sapiens] [Complex:9015343] Factor IIa inhibitors (compounds):IIa [extracellular region] [Homo sapiens] [Complex:9603322] Factor IIa inhibitors (peptide):IIa [extracellular region] [Homo sapiens] [Complex:9748705] Thrombin:F2R [plasma membrane] [Homo sapiens] [Complex:9853536] FIIa:GP1BA:GP1BB:GP9:GP5:VWF:collagen type I [plasma membrane] [Homo sapiens]
(hasMember)	[DefinedSet:791492] Ligands of GPCRs that activate Gq/11 [extracellular region] [Homo sapiens] [CandidateSet:8852723] Activated thrombin, (ELANE) [extracellular region] [Homo sapiens]
(input)	[Reaction:140791] activated thrombin (factor IIa) + antithrombin III:heparan sulfate -> thrombin:antithrombin III:heparan sulfate [Homo sapiens] [Reaction:141046] activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin [Homo sapiens] [Reaction:389463] Proteinase-activated receptors can bind thrombin [Homo sapiens] [Reaction:429529] Thrombin binding to GP1b:IX:V [Homo sapiens] [Reaction:913591] GPIb-IX-V binds thrombin [Homo sapiens] [Reaction:5578883] Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) [Homo sapiens] [Reaction:9015379] Factor IIa inhibitors (compounds) binds IIa [Homo sapiens] [Reaction:9603302] Factor IIa inhibitors (peptide) bind IIa [Homo sapiens] [Reaction:9853533] Thrombin binds to GP1b:IX:V (replace 429529?) [Homo sapiens]
(output)	[Reaction:140664] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) [Homo sapiens] [Reaction:140700] prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) [Homo sapiens]
(physicalEntity)	[CatalystActivity:139890] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
(updatedInstance)	[_UpdateTracker:9869340] Update Tracker - [Complex:156786] activated thrombin (factor IIa) [extracellular region] - v33:[modifyName]
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No pathways have been reviewed or authored by activated thrombin (factor IIa) [extracellular region] (156786)