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Details on Person UniProt:Q9Y266 NUDC
| Class:Id | ReferenceGeneProduct:156715 |
|---|---|
| _chainChangeLog | chain:1-331 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Y266 NUDC |
| _timestamp | 2026-02-20 22:57:55 |
| chain | chain:1-331 |
| checksum | 34F591170F7594AF |
| comment | FUNCTION Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (PubMed:12679384, PubMed:12852857, PubMed:25789526). Necessary for cytokinesis and cell proliferation (PubMed:12679384, PubMed:12852857).SUBUNIT Interacts with PAFAH1B1 (By similarity). Interacts with PLK1 (PubMed:12852857). Part of a complex containing PLK1, NUDC, dynein and dynactin (PubMed:12852857). Interacts with DCDC1 (PubMed:22159412). Interacts with EML4 (via WD repeats) (PubMed:25789526).SUBCELLULAR LOCATION In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern. Localizes to the mitotic spindle in a EML4-dependent manner (PubMed:25789526).TISSUE SPECIFICITY Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.INDUCTION Up-regulated in actively dividing hematopoietic precursor cells. Up-regulated in cultured erythroleukemia TF-1 cells by granulocyte-macrophage colony-stimulating factor. Strongly down-regulated during maturation of erythroid precursor cells.PTM Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases.SIMILARITY Belongs to the nudC family. |
| created | [InstanceEdit:156670] Gillespie, ME, 2004-12-09 02:18:13 |
| description | recommendedName: Nuclear migration protein nudC alternativeName: Nuclear distribution protein C homolog |
| geneName | NUDC |
| identifier | Q9Y266 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cell cycle Cell division Coiled coil Cytoplasm Cytoskeleton Microtubule Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | NUDC |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001936] ENSEMBL:ENSG00000090273 NUDC [Homo sapiens] |
| secondaryIdentifier | NUDC_HUMAN Q5QP31 Q5QP35 Q9H0N2 Q9Y2B6 |
| sequenceLength | 331 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:156702] p-S274,S326-NUDC [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:156716] NUDC [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:377731] NUDC [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9648125] p-S274,S326-NUDC [spindle] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:156689] O-phospho-L-serine at 326 [ModifiedResidue:156726] O-phospho-L-serine at 274 |
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No pathways have been reviewed or authored by UniProt:Q9Y266 NUDC (156715)
