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Details on Person *Plk1 is shown to phosphorylate Wee1A, an event that is like...
| Class:Id | Summation:156684 |
|---|---|
| _displayName | *Plk1 is shown to phosphorylate Wee1A, an event that is like... |
| _timestamp | 2008-05-11 23:50:19 |
| created | [InstanceEdit:156701] Lee, KS, 2004-12-08 21:18:23 |
| literatureReference | [LiteratureReference:162979] Negative regulation of the wee1 protein kinase by direct action of the nim1/cdr1 mitotic inducer [LiteratureReference:162972] Phosphorylation and inactivation of the mitotic inhibitor Wee1 by the nim1/cdr1 kinase |
| modified | [InstanceEdit:162993] Gillespie, ME, 2005-04-12 02:12:05 [InstanceEdit:164605] Gillespie, ME, 2005-06-03 00:35:11 [InstanceEdit:349581] Matthews, L, 2008-05-11 23:49:32 |
| text | *Plk1 is shown to phosphorylate Wee1A, an event that is likely critical for recognition and ubiquitination of Wee1A by SCF and therefore for the subsequent degradation of Wee1A . **Plk1 phosphorylates Wee1A at S53, creating the second phosphodegron, PD53. ** Evidence also exists in budding yeast that the budding yeast polo homolog Cdc5 directly phosphorylates and down-regulate the budding yeast Wee1 ortholog Swe1. Thus, polo kinase-dependent phosphorylation and degradation of Wee1A (or Swe1) is likely conserved throughout evolution and is critical for normal mitotic entry. |
| (summation) | [Reaction:156699] Inactivation of Wee1 kinase [Homo sapiens] |
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No pathways have been reviewed or authored by *Plk1 is shown to phosphorylate Wee1A, an event that is like... (156684)
