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Details on Person Activation of Cdc25C

Class:IdReaction:156678
_displayNameActivation of Cdc25C
_doReleaseTRUE
_timestamp2022-02-08 21:50:30
authored[InstanceEdit:156701] Lee, KS, 2004-12-08 21:18:23
catalystActivity[CatalystActivity:3000343] protein serine/threonine kinase activity of p-T210-PLK1 [cytosol]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:156670] Gillespie, ME, 2004-12-09 02:18:13
edited[InstanceEdit:165085] Gillespie, ME, 0000-00-00 00:00:00
figure[Figure:162990] /figures/polokinases_Cdc25C.jpg
goBiologicalProcess[GO_BiologicalProcess:171508] regulation of cell cycle
input[EntityWithAccessionedSequence:157879] CDC25C [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:162964] Plk1 promotes nuclear translocation of human Cdc25C during prophase
[LiteratureReference:156692] Purification and molecular cloning of Plx1, a Cdc25-regulatory kinase from Xenopus egg extracts
modified[InstanceEdit:158098] Gillespie, ME, 2005-01-19 16:42:13
[InstanceEdit:158099] Gillespie, ME, 2005-01-19 16:55:25
[InstanceEdit:162999] Gillespie, ME, 2005-04-12 02:12:36
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:164606] Gillespie, ME, 2005-06-03 00:55:05
[InstanceEdit:170262] Matthews, L, 2006-01-04 01:10:23
[InstanceEdit:258122] Kanapin, EE, 2008-03-27 12:15:20
[InstanceEdit:387142] Matthews, L, 2008-12-01 05:48:41
[InstanceEdit:1546201] D'Eustachio, P, 2011-08-27
[InstanceEdit:2671731] D'Eustachio, P, 2012-11-23
[InstanceEdit:8861951] Orlic-Milacic, Marija, 2016-02-22
[InstanceEdit:8933147] Orlic-Milacic, Marija, 2016-08-03
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8981702] Orlic-Milacic, Marija, 2017-03-13
[InstanceEdit:9764039] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActivation of Cdc25C
negativePrecedingEvent[NegativePrecedingEvent:9764024] Futile Cycle: PLK1 phosphorylates BORA
[NegativePrecedingEvent:9764038] Futile Cycle: PLK1 phosphorylates GTSE1
output[EntityWithAccessionedSequence:8981697] p-S198-CDC25C [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2005-04-11
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358767] R-HSA-156678.7
summation[Summation:156710] PLK1 phosphorylates CDC25C on serine residue S198. In additi...
(hasEvent)[Pathway:156711] Polo-like kinase mediated events [Homo sapiens]
(precedingEvent)[Reaction:170149] Translocation of active Cdc25C to the nucleus [Homo sapiens]
[Reaction:170159] Translocation of Cdc25 to the nucleus [Homo sapiens]
(updatedInstance)[_UpdateTracker:9781239] Update Tracker - [Reaction:156678] Activation of Cdc25C - v61:[addLiteratureReference, add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText]
[_UpdateTracker:9787105] Update Tracker - [Reaction:156678] Activation of Cdc25C - v46:[modifyText]
[_UpdateTracker:9789439] Update Tracker - [Reaction:156678] Activation of Cdc25C - v38:[addInput, addOutput]
[_UpdateTracker:9791692] Update Tracker - [Reaction:156678] Activation of Cdc25C - v27:[add_removeInput]
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No pathways have been reviewed or authored by Activation of Cdc25C (156678)