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Details on Person CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO

Class:Id	Reaction:156526
_displayName	CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO
_doRelease	TRUE
_timestamp	2014-11-20 02:53:59
authored	[InstanceEdit:5423628] Jassal, Bijay, 2014-05-09
catalystActivity	[CatalystActivity:5423603] monooxygenase activity of CYP1A2,3A4,3A5,2A13 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:156525] Jassal, B, 2004-11-18 15:03:00
edited	[InstanceEdit:5423628] Jassal, Bijay, 2014-05-09
input	[SimpleEntity:5423605] AFB1 [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29368] O2 [cytosol]
literatureReference	[LiteratureReference:5423613] The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4 [LiteratureReference:5423601] Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract
modified	[InstanceEdit:156539] Jassal, B, 2004-11-19 09:05:24 [InstanceEdit:158096] Schmidt, EE, 2005-01-19 11:00:53 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:352324] Jassal, B, 2008-06-02 12:56:30 [InstanceEdit:615503] Jassal, B, 2010-04-21 [InstanceEdit:617354] Jassal, B, 2010-04-21 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:2993442] Jassal, B, 2013-01-18 [InstanceEdit:5423614] Jassal, Bijay, 2014-05-09 [InstanceEdit:5423722] Jassal, Bijay, 2014-05-09 [InstanceEdit:5467309] Jassal, Bijay, 2014-05-16 [InstanceEdit:5545506] Jassal, Bijay, 2014-05-22 [InstanceEdit:5566525] Jassal, Bijay, 2014-05-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO Aflatoxin B1 oxidized to Aflatoxin-8,9-oxide
output	[SimpleEntity:159211] AFXBO [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5545505] D'Eustachio, Peter, 2014-05-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5645071] R-HSA-156526.2
summation	[Summation:156528] Aflatoxin B1 (AFB1) requires microsomal oxidation to produce...
(hasEvent)	[Pathway:5423646] Aflatoxin activation and detoxification [Homo sapiens]
(precedingEvent)	[Reaction:176059] GST trimers transfer GS from GSH to luminal substrates [Homo sapiens] [Reaction:5423653] MGST trimers transfer GS from GSH to AFXBO and AFNBO [Homo sapiens] [Reaction:5423656] AFXBO hydrolyses non-enzymatically to AFBDHD [Homo sapiens] [BlackBoxEvent:5423728] AFXBO translocates from cytosol to nucleoplasm [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9792096] Update Tracker - [Reaction:156526] CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO - v24:[modifyText]
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No pathways have been reviewed or authored by CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO (156526)