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Details on Person Collagen X is thought to form extended hexagonal networks (K...

Class:Id	Summation:1564152
_displayName	Collagen X is thought to form extended hexagonal networks (K...
_timestamp	2012-09-26 13:16:55
created	[InstanceEdit:1564189] Jupe, S, 2011-09-05
literatureReference	[LiteratureReference:2210353] Macromolecular organization of chicken type X collagen in vitro [LiteratureReference:2470587] A dominant interference collagen X mutation disrupts hypertrophic chondrocyte pericellular matrix and glycosaminoglycan and proteoglycan distribution in transgenic mice [LiteratureReference:2161367] Metabolism of low molecular weight collagen by chondrocytes obtained from histologically distinct zones of the chick embryo tibiotarsus [LiteratureReference:2161264] Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy [LiteratureReference:2161236] Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice [LiteratureReference:2470554] A type X collagen mutation causes Schmid metaphyseal chondrodysplasia [LiteratureReference:2470581] COL10A1 nonsense and frame-shift mutations have a gain-of-function effect on the growth plate in human and mouse metaphyseal chondrodysplasia type Schmid [LiteratureReference:2470540] Schmid-type metaphyseal chondrodysplasia as the result of a collagen type X defect due to a novel COL10A1 nonsense mutation: A case report of a novel COL10A1 mutation [LiteratureReference:1564101] Type X collagen contains two cleavage sites for a vertebrate collagenase [LiteratureReference:1564072] Differential susceptibility of type X collagen to cleavage by two mammalian interstitial collagenases and 72-kDa type IV collagenase [LiteratureReference:1564091] Type X collagen degradation in long-term serum-free culture of the embryonic chick tibia following production of active collagenase and gelatinase [LiteratureReference:1458402] Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage [LiteratureReference:1564199] The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction [LiteratureReference:2168931] Cleavage of type VIII collagen by human neutrophil elastase
modified	[InstanceEdit:2161296] Jupe, S, 2012-03-14 [InstanceEdit:2168010] Jupe, S, 2012-03-23 [InstanceEdit:2470547] Jupe, S, 2012-09-19 [InstanceEdit:2482200] Jupe, S, 2012-09-25 [InstanceEdit:2484855] Jupe, S, 2012-09-26
text	Collagen X is thought to form extended hexagonal networks (Kwan et al. 1991, Jacenko et al. 2001). It's distribution is limited to regions of hypertrophic cartilage destined for degradation during endochondral ossification (Schmid & Conrad 1982). It is also found in areas of surface fibrillation and osteophyte formation during the development of osteoarthritic lesions in articular cartilage (von der Mark et al. 1992). In Timp3 knockout mice type X collagen was observed mostly in areas of articular cartilage that stained strongly for collagen cleavage products, suggesting that deposition of type X collagen might be a damage repair mechanism (Sahebjam et al. 2007). Mutations in the gene COL10A1 are associated with Schmid/Japanese type metaphyseal chondrodysplasia (SMCD) (Warman et al. 1993, Ho et al. 2007, Woelfle et al. 2011). Type X collagen is degraded by MMP1 (Schmid et al. 1986, Welgus et al. 1990, Cole et al. 1993), MMP2 (Cole et al. 1993, Welgus et al. 1990), MMP3 (Wu et al. 1991), MMP13 (Knauper et al. 1997) and neutrophil elastase (Kittelberger et al. 1992).
(summation)	[Reaction:1564143] Collagen type X degradation by MMP1,2 [Homo sapiens]
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