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Details on Person Type V collagen is a fibril-forming collagen forming a group...

Class:Id	Summation:1564135
_displayName	Type V collagen is a fibril-forming collagen forming a group...
_timestamp	2012-09-28 16:00:00
created	[InstanceEdit:1564189] Jupe, S, 2011-09-05
literatureReference	[LiteratureReference:1981107] Collagens--structure, function, and biosynthesis [LiteratureReference:1606367] Collagen type I and type V are present in the same fibril in the avian corneal stroma [LiteratureReference:1606361] Type V collagen controls the initiation of collagen fibril assembly [LiteratureReference:2482189] Mutations of the alpha2(V) chain of type V collagen impair matrix assembly and produce ehlers-danlos syndrome type I [LiteratureReference:2482203] Null alleles of the COL5A1 gene of type V collagen are a cause of the classical forms of Ehlers-Danlos syndrome (types I and II) [LiteratureReference:1564133] Metalloproteinases from rabbit bone culture medium degrade types IV and V collagens, laminin and fibronectin [LiteratureReference:2161248] MMP mediated type V collagen degradation (C5M) is elevated in ankylosing spondylitis [LiteratureReference:1474211] Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases [LiteratureReference:1564207] Partial purification of collagenase and gelatinase from human polymorphonuclear leucocytes. Analysis of their actions on soluble and insoluble collagens [LiteratureReference:1564195] Characteristics of 92 kDa type IV collagenase/gelatinase produced by granulocytic leukemia cells: structure, expression of cDNA in E. coli and enzymic properties [LiteratureReference:2470246] A 92 kDa gelatinase (MMP-9) cleavage site in native type V collagen [LiteratureReference:1564188] Matrix metalloproteinase-9 (92 kDa gelatinase/type IV collagenase) from U937 monoblastoid cells: correlation with cellular invasion
modified	[InstanceEdit:2161296] Jupe, S, 2012-03-14 [InstanceEdit:2470244] Jupe, S, 2012-09-17 [InstanceEdit:2482200] Jupe, S, 2012-09-25 [InstanceEdit:2485082] Jupe, S, 2012-09-28
text	Type V collagen is a fibril-forming collagen forming a group with collagen types I, II, III and XI (Gelse et al. 2003). Three different alpha chains exist that can combine in three distinct trimers. Collagen V forms fibrils that are associated with type I and to a lesser extent III collagen, as a minor but critical component of bone matrix, corneal stroma and the interstitial matrix of muscle, liver, lung and placenta (Birk et al. 1988). COL5A1-/- mice have an almost complete lack of collagen fibrils reflecting a central role in fibrillogenesis (Wenstrup et al. 2004). Type V collagen mutation results in a range of connective tissue diseases including Ehlers-Danlos syndrome (EDS), which is a heterogeneous group of disorders characterized by joint hypermobility and skin hyperextensibility, thinness and fragility. These result from mutations in the COL5A1 and COL5A2 genes (Michalickova et al. 1998, Schwarze et al. 2000). Type V collagen is digested by MMP2 (Murphy et al. 1981, Veidal et al. 2011), MMP10 (Nicholson et al. 1989), and MMP9 (Murphy et al. 1982, Watanabe et al. 1993, Pourmotabbed et al. 1994, Niyibizi et al. 1994, Veidal et al. 2011).
(summation)	[Reaction:1564164] Collagen type V degradation by MMP2,9,10 [Homo sapiens]
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