Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q8N5P1 ZC3H8
| Class:Id | ReferenceGeneProduct:156330 |
|---|---|
| _chainChangeLog | chain:1-291 added on Fri February 6 2015 |
| _displayName | UniProt:Q8N5P1 ZC3H8 |
| _timestamp | 2024-11-03 19:49:36 |
| chain | chain:1-291 |
| checksum | 5DFDA42280916034 |
| comment | FUNCTION Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:23932780). Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.SUBUNIT Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with ICE1 (via C-terminus domain).SUBCELLULAR LOCATION Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.DOMAIN The N-terminal region and all three C3H1-type zinc fingers are necessary to induce transcriptional repression. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Zinc finger CCCH domain-containing protein 8 |
| geneName | ZC3H8 ZC3HDC8 |
| identifier | Q8N5P1 |
| isSequenceChanged | FALSE |
| keyword | Apoptosis Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Repressor RNA-binding Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ZC3H8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002150] ENSEMBL:ENSG00000144161 ZC3H8 [Homo sapiens] |
| secondaryIdentifier | ZC3H8_HUMAN Q9BZ75 |
| sequenceLength | 291 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:6807406] ZC3H8 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8N5P1 ZC3H8 (156330)
