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Details on Person UniProt:Q969T4 UBE2E3
| Class:Id | ReferenceGeneProduct:155473 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-207 added on Fri February 6 2015;initiator methionine:1 for 155473 removed on Fri Nov 03 2023;initiator methionine: for 155473 added on Fri Nov 03 2023;initiator methionine: for 155473 removed on Fri Aug 15 2025;initiator methionine:1 for 155473 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q969T4 UBE2E3 |
| _timestamp | 2025-08-15 21:58:01 |
| chain | initiator methionine:1 chain:2-207 |
| checksum | 821CB1382478DC9F |
| comment | FUNCTION Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells.CATALYTIC ACTIVITY S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT The ubiquitin-loaded form interacts specifically with importin-11 (IPO11), leading to its import into the nucleus. Interacts with NEDD4L.INTERACTION Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner.TISSUE SPECIFICITY Ubiquitously expressed at low levels. Highly expressed in skeletal muscle.SIMILARITY Belongs to the ubiquitin-conjugating enzyme family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Ubiquitin-conjugating enzyme E2 E3 ecNumber evidence="7"2.3.2.23 alternativeName: E2 ubiquitin-conjugating enzyme E3 alternativeName: UbcH9 alternativeName: Ubiquitin carrier protein E3 alternativeName: Ubiquitin-conjugating enzyme E2-23 kDa alternativeName: Ubiquitin-protein ligase E3 |
| geneName | UBE2E3 UBCE4 UBCH9 |
| identifier | Q969T4 |
| isSequenceChanged | FALSE |
| keyword | Acetylation ATP-binding Cytoplasm Growth regulation Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transferase Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | UBE2E3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994588] ENSEMBL:ENSG00000170035 UBE2E3 [Homo sapiens] |
| secondaryIdentifier | UB2E3_HUMAN B2RAD6 D3DPG3 Q5U0R7 Q7Z4W4 |
| sequenceLength | 207 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:947633] UBE2E3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8852108] UBE2E3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:8864162] Ub-C145-UBE2E3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8864208] Ub-C145-UBE2E3 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8864166] S-(glycyl)-L-cysteine (Cys-Gly) at 145 |
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No pathways have been reviewed or authored by UniProt:Q969T4 UBE2E3 (155473)
