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Details on Person UniProt:Q70CQ3 USP30
| Class:Id | ReferenceGeneProduct:155459 |
|---|---|
| _chainChangeLog | chain:1-517 added on Fri February 6 2015 |
| _displayName | UniProt:Q70CQ3 USP30 |
| _timestamp | 2024-11-03 20:03:49 |
| chain | chain:1-517 |
| checksum | 68FA9B9BEBCFF8DF |
| comment | FUNCTION Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).CATALYTIC ACTIVITY Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).ACTIVITY REGULATION Inhibited by the diterpenoid derivative 15-oxospiramilactone (S3).INTERACTION Expressed in skeletal muscle, pancreas, liver and kidney.PTM Ubiquitinated by parkin (PRKN) at Lys-235 and Lys-289, leading to its degradation.SIMILARITY Belongs to the peptidase C19 family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Ubiquitin carboxyl-terminal hydrolase 30 ecNumber evidence="6"3.4.19.12 alternativeName: Deubiquitinating enzyme 30 alternativeName: Ubiquitin thioesterase 30 alternativeName: Ubiquitin-specific-processing protease 30 shortName: Ub-specific protease 30 |
| geneName | USP30 |
| identifier | Q70CQ3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Hydrolase Isopeptide bond Membrane Mitochondrion Mitochondrion outer membrane Protease Proteomics identification Reference proteome Thiol protease Transmembrane Transmembrane helix Ubl conjugation Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | USP30 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988747] ENSEMBL:ENSG00000135093 USP30 [Homo sapiens] |
| secondaryIdentifier | UBP30_HUMAN Q8WTU7 Q96JX4 Q9BSS3 |
| sequenceLength | 517 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5696931] USP30 [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:9674135] USP30 [peroxisomal membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q70CQ3 USP30 (155459)
