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Details on Person UniProt:Q91YR1 Twf1
| Class:Id | ReferenceGeneProduct:155361 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-350 added on Fri February 6 2015;initiator methionine:1 for 155361 removed on Fri Nov 03 2023;initiator methionine: for 155361 added on Fri Nov 03 2023;initiator methionine: for 155361 removed on Fri Aug 15 2025;initiator methionine:1 for 155361 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q91YR1 Twf1 |
| _timestamp | 2025-08-15 21:42:28 |
| chain | initiator methionine:1 chain:2-350 |
| checksum | 643CBBA18D38D4E0 |
| comment | FUNCTION Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.SUBUNIT Interacts with G-actin; ADP-actin form and capping protein (CP) (PubMed:12807912, PubMed:15282541, PubMed:16511569). May also be able to interact with TWF2 and phosphoinositides, PI(4,5)P2 (PubMed:12807912). When bound to PI(4,5)P2, it is down-regulated (PubMed:12807912). Interacts with ACTG1 (By similarity).INTERACTION Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts.TISSUE SPECIFICITY Widely expressed with highest levels in brain, liver and kidney. Also expressed in heart, lung and testis. Not detected in spleen or skeletal muscle.DEVELOPMENTAL STAGE Expression was widespread throughout the embryonic stages analyzed; 10.5 dpc, 12.5 dpc, 14.5 dpc and 18.5 dpc. At 14.5 dpc, strongest expression was observed in the developing central and peripheral nervous system (CNS and PNS, respectively) and in the olfactory sensory epithelium. In the CNS, the proliferating neuronal precursors in the ventricular zone expressed it more than the postmitotic neurons. At 18.5 dpc, highest expression levels were detected in the mechanosensory hair cells of the inner ear and in the differentiated keratinocytes of the skin.PTM Phosphorylated on serine and threonine residues.SIMILARITY Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.ONLINE INFORMATION Molecular embrace - Issue 73 of August 2006 |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Twinfilin-1 alternativeName: Protein A6 |
| geneName | Twf1 Ptk9 |
| identifier | Q91YR1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Actin-binding Cytoplasm Cytoskeleton Phosphoprotein Reference proteome Repeat |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Twf1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TWF1_MOUSE O09132 Q52L77 Q80X09 |
| sequenceLength | 350 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9667694] Twf1 [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q91YR1 Twf1 (155361)
