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Details on Person UniProt:Q16288-3 NTRK3
| Class:Id | ReferenceIsoform:155205 |
|---|---|
| _chainChangeLog | signal peptide:1-31 added on Fri February 6 2015;chain:32-839 added on Fri February 6 2015 |
| _displayName | UniProt:Q16288-3 NTRK3 |
| _timestamp | 2025-02-21 18:49:44 |
| chain | signal peptide:1-31 chain:32-839 |
| checksum | 7FE8846830083C08 |
| comment | FUNCTION Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)SUBUNIT Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity). Interacts with PTPRS (PubMed:25385546). Interacts with MAPK8IP3/JIP3 (By similarity).INTERACTION Additional isoforms seem to exist.TISSUE SPECIFICITY Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.PTM Ligand-mediated auto-phosphorylation.DISEASE Defects in NTRK3 are associated with susceptibility to congenital heart defects (CHD). A disease characterized by congenital developmental abnormalities involving structures of the heart. CHD are the most common major birth defects and the leading cause of death from congenital malformations.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. |
| description | recommendedName: NT-3 growth factor receptor ecNumber: 2.7.10.1 alternativeName: GP145-TrkC shortName: Trk-C alternativeName: Neurotrophic tyrosine kinase receptor type 3 alternativeName: TrkC tyrosine kinase |
| geneName | NTRK3 TRKC |
| identifier | Q16288 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Developmental protein Differentiation Direct protein sequencing Disulfide bond Glycoprotein Immunoglobulin domain Kinase Leucine-rich repeat Membrane Neurogenesis Nucleotide-binding Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Signal Transferase Transmembrane Transmembrane helix Tyrosine-protein kinase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | NTRK3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993781] ENSEMBL:ENSG00000140538 NTRK3 [Homo sapiens] |
| secondaryIdentifier | NTRK3_HUMAN B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 |
| sequenceLength | 839 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q16288-3 |
| (referenceSequence) | [ModifiedResidue:166452] O4'-phospho-L-tyrosine at 490 [ModifiedResidue:166453] O4'-phospho-L-tyrosine at 670 [ModifiedResidue:166461] O4'-phospho-L-tyrosine at 675 [ModifiedResidue:166493] O4'-phospho-L-tyrosine at 785 [ModifiedResidue:166518] O4'-phospho-L-tyrosine at 674 |
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No pathways have been reviewed or authored by UniProt:Q16288-3 NTRK3 (155205)
