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Details on Person UniProt:P67936-2 TPM4
| Class:Id | ReferenceIsoform:155096 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-248 added on Sat February 7 2015;initiator methionine:1 for 155096 removed on Fri Nov 03 2023;initiator methionine: for 155096 added on Fri Nov 03 2023;initiator methionine: for 155096 removed on Fri Aug 15 2025;initiator methionine:1 for 155096 added on Fri Aug 15 2025 |
| _displayName | UniProt:P67936-2 TPM4 |
| _timestamp | 2025-08-15 21:34:48 |
| chain | initiator methionine:1 chain:2-248 |
| checksum | 5D5CDF6BF76552A8 |
| comment | FUNCTION Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). Plays a role in platelet biogenesis.SUBUNIT Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.INTERACTION Associates with F-actin stress fibers.ALTERNATIVE PRODUCTS Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level).DOMAIN The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the tropomyosin family. |
| description | recommendedName: Tropomyosin alpha-4 chain alternativeName: TM30p1 alternativeName: Tropomyosin-4 |
| geneName | TPM4 |
| identifier | P67936 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Acetylation Actin-binding Alternative splicing Calcium Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Metal-binding Muscle protein Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | TPM4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8958623] ENSEMBL:ENSG00000167460 TPM4 [Homo sapiens] |
| secondaryIdentifier | TPM4_HUMAN P07226 Q15659 Q5U0D9 Q9BU85 Q9H8Q3 Q9UCS1 Q9UCS2 Q9UCS3 Q9UCS4 |
| sequenceLength | 248 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P67936-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P67936-2 TPM4 (155096)
