Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P06753-2 TPM3
| Class:Id | ReferenceIsoform:155089 |
|---|---|
| _chainChangeLog | chain:1-285 added on Sat February 7 2015;chain:1-285 removed on Fri May 8 2015;initiator methionine:1 added on Fri May 8 2015;chain:2-285 added on Fri May 8 2015;initiator methionine: for 155089 added on Sun February 16 2020;initiator methionine: for 155089 added on Sun February 16 2020;initiator methionine:1 for 155089 removed on Fri Nov 03 2023;initiator methionine: for 155089 removed on Fri Aug 15 2025;initiator methionine: for 155089 removed on Fri Aug 15 2025;initiator methionine: for 155089 removed on Fri Aug 15 2025;initiator methionine:1 for 155089 added on Fri Aug 15 2025;initiator methionine:1 for 155089 added on Fri Aug 15 2025;initiator methionine:1 for 155089 added on Fri Aug 15 2025 |
| _displayName | UniProt:P06753-2 TPM3 |
| _timestamp | 2025-08-15 21:34:47 |
| chain | initiator methionine:1 chain:2-285 initiator methionine:1 initiator methionine:1 |
| checksum | 99EAD24C45460A14 |
| comment | FUNCTION Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.SUBUNIT Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain (By similarity). Interacts with TMOD1 (PubMed:8002995). Interacts with TNNT1 (PubMed:35510366).INTERACTION Additional isoforms seem to exist.DOMAIN The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE A chromosomal aberration involving TPM3 is found in papillary thyroid carcinomas (PTCs). A rearrangement with NTRK1 generates the TRK fusion transcript by fusing the amino end of isoform 2 of TPM3 to the 3'-end of NTRK1.MISCELLANEOUS Peptides 2-27, 41-55, 132-153, 163-169, 216-225 and 237-248 have been identified and sequenced by MS. PubMed:16201836 (ABC40673) sequence corresponds to a TPM3 retrocopy (rcTPM3) on chromosome 16 that is generated by retroposition of reversed transcribed mRNA back to the genome. rcTPM3 functionality is uncertain. It has been detected by MS in primary breast cancer tissues.MISCELLANEOUS Peptides 2-27, 41-55, 132-153 and 163-169 have been identified and sequenced by MS.SIMILARITY Belongs to the tropomyosin family.CAUTION It is uncertain whether Met-1 or Met-2 is the initiator. |
| description | recommendedName: Tropomyosin alpha-3 chain alternativeName: Gamma-tropomyosin alternativeName: Tropomyosin-3 alternativeName: Tropomyosin-5 shortName: hTM5 |
| geneName | TPM3 |
| identifier | P06753 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Actin-binding Alternative splicing Chromosomal rearrangement Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Muscle protein Nemaline myopathy Phosphoprotein Proteomics identification Proto-oncogene Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | TPM3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8961049] ENSEMBL:ENSG00000143549 TPM3 [Homo sapiens] |
| secondaryIdentifier | TPM3_HUMAN D3DV71 P12324 Q2QD06 Q5VU58 Q5VU63 Q5VU66 Q5VU71 Q5VU72 Q8TCG3 Q969Q2 Q9NQH8 |
| sequenceLength | 285 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P06753-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P06753-2 TPM3 (155089)
