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Details on Person PPTN11 dephosphorylates SPRY2

Class:Id	Reaction:1549564
_displayName	PPTN11 dephosphorylates SPRY2
_doRelease	TRUE
_timestamp	2017-03-10 17:56:57
authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity	[CatalystActivity:210262] protein tyrosine phosphatase activity of PTPN11 [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1549562] Rothfels, K, 2011-08-30
input	[Complex:1295625] PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1549561] Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty [LiteratureReference:1112732] The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway
modified	[InstanceEdit:1580767] Rothfels, K, 2011-09-07 [InstanceEdit:5654532] Rothfels, Karen, 2014-12-03 [InstanceEdit:8862670] Rothfels, Karen, 2016-02-29 [InstanceEdit:8981545] Rothfels, Karen, 2017-03-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PPTN11 dephosphorylates SPRY2
output	[EntityWithAccessionedSequence:74686] GRB2-1 [cytosol] [Homo sapiens] [Complex:934598] PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1295613] SPRY2 binds GRB2 [Homo sapiens] [Reaction:1295609] SRC phosphorylates SPRY2 on Y55 and Y227 [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591373] R-HSA-1549564.4
summation	[Summation:1549559] PPTN11 (also known as SHP2) may exert its positive effects o...
(hasEvent)	[Pathway:1295596] Spry regulation of FGF signaling [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784908] Update Tracker - [Reaction:1549564] PPTN11 dephosphorylates SPRY2 - v52:[modifyText]
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No pathways have been reviewed or authored by PPTN11 dephosphorylates SPRY2 (1549564)