Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:Q92734 TFG

Class:Id	ReferenceGeneProduct:154850
_chainChangeLog	chain:1-400 added on Sat February 7 2015
_displayName	UniProt:Q92734 TFG
_timestamp	2024-11-03 20:21:51
chain	chain:1-400
checksum	D8A559D0F7314D1F
comment	FUNCTION Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858).SUBUNIT Self-associates to form an oligomeric complex (PubMed:23479643). Interacts with PDCD6; promoting localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Interacts with SEC16B (PubMed:21478858).INTERACTION Localizes to endoplasmic reticulum exit site (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:21478858, PubMed:27813252).ALTERNATIVE PRODUCTS Ubiquitous.DISEASE A chromosomal aberration involving TFG is found in papillary thyroid carcinomas (PTCs). Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.
created	[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10
description	recommendedName: Protein TFG alternativeName: TRK-fused gene protein
geneName	TFG
identifier	Q92734
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Chromosomal rearrangement Coiled coil Direct protein sequencing Disease variant Endoplasmic reticulum ER-Golgi transport Hereditary spastic paraplegia Methylation Neurodegeneration Neuropathy Phosphoprotein Proteomics identification Proto-oncogene Reference proteome Transport
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	TFG
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8999204] ENSEMBL:ENSG00000114354 TFG [Homo sapiens]
secondaryIdentifier	TFG_HUMAN D3DN49 G5E9V1 K0J5S8 K0J6K2 Q15656 Q969I2
sequenceLength	400
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8972609] UniProt:Q92734-1 TFG [Homo sapiens] [ReferenceIsoform:8972610] UniProt:Q92734-2 TFG [Homo sapiens] [ReferenceIsoform:8972611] UniProt:Q92734-3 TFG [Homo sapiens] [ReferenceIsoform:8972612] UniProt:Q92734-4 TFG [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:5688159] TFG [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9699806] TFG(1-240)-ALK(1058-1620) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9699874] TFG(1-138)-ALK(1058-1620) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9699887] TFG(1-193)-ALK(1058-1620) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9702019] TFG(1-138)-p-7Y-ALK(1058-1620) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9702029] TFG(1-193)-p-7Y-ALK(1058-1620) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9702038] TFG(1-240)-p-7Y-ALK(1058-1620) fusion [cytosol] [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:Q92734 TFG (154850)