Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9Y2Z4 YARS2
| Class:Id | ReferenceGeneProduct:154595 |
|---|---|
| _chainChangeLog | transit peptide:1-16 added on Sat February 7 2015;chain:17-477 added on Sat February 7 2015 |
| _displayName | UniProt:Q9Y2Z4 YARS2 |
| _timestamp | 2026-02-20 21:44:56 |
| chain | transit peptide:1-16 chain:17-477 |
| checksum | C513B8FE1E7A09E4 |
| comment | FUNCTION Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).CATALYTIC ACTIVITY tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)SUBUNIT Homodimer.SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the class-I aminoacyl-tRNA synthetase family. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Tyrosine--tRNA ligase, mitochondrial ecNumber evidence="5 6"6.1.1.1 alternativeName: Tyrosyl-tRNA synthetase shortName evidence="10"TyrRS |
| geneName | YARS2 CGI-04 |
| identifier | Q9Y2Z4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Aminoacyl-tRNA synthetase ATP-binding Disease variant Ligase Mitochondrion Nucleotide-binding Primary mitochondrial disease Protein biosynthesis Proteomics identification Reference proteome Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | YARS2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8957715] ENSEMBL:ENSG00000139131 YARS2 [Homo sapiens] |
| secondaryIdentifier | SYYM_HUMAN D3DUW8 Q9H817 |
| sequenceLength | 477 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:379634] YARS2 [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:8958371] YARS2 [extracellular region] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9Y2Z4 YARS2 (154595)
