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Details on Person UniProt:Q60864 Stip1
| Class:Id | ReferenceGeneProduct:154401 |
|---|---|
| _chainChangeLog | chain:1-543 added on Fri February 6 2015 |
| _displayName | UniProt:Q60864 Stip1 |
| _timestamp | 2023-11-03 17:08:37 |
| chain | chain:1-543 |
| checksum | B737FBA92B198D6C |
| comment | FUNCTION Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90.SUBUNIT Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (By similarity). Forms a complex with HSPA8/HSC70, HSPCA/HSP-86 and HSPCB/HSP-84 (PubMed:8999875). Interacts with PACRG. Interacts with EEF1AKMT3 (By similarity). Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction. Interacts with FLCN, FNIP1 and FNIP2. Interacts with HSPA8/HSC70 (By similarity). Interacts with HSP90AB1; upon SMYD2-dependent HSP90AB1 methylation (By similarity).SUBCELLULAR LOCATION The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90 (By similarity).PTM In vitro kinase assay failed to detect phosphorylation by MAPKAPK2. |
| created | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 |
| description | recommendedName: Stress-induced-phosphoprotein 1 shortName: STI1 shortName: mSTI1 alternativeName: Hsc70/Hsp90-organizing protein shortName: Hop |
| geneName | Stip1 |
| identifier | Q60864 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cytoplasm Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Reference proteome Repeat TPR repeat Ubl conjugation |
| modified | [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5083144] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9607352] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Stip1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | STIP1_MOUSE Q3TT16 Q8BPH3 Q99L66 |
| sequenceLength | 543 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:444987] STIP1_MOUSE [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q60864 Stip1 (154401)
